Protein Alignment hep and KIC1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 1121
• Identity: 231/1121 - (20%)
• Similarity: 411/1121 - (36%)
• Gaps: 267/1121 - (23%)

  Fly   193 DINDL-KHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYI 256
            |::.| |....:|.|..|.|.|..::.:..:.|:|.:....:::|.:.:..::..:........|
Yeast    18 DVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNI 82

  Fly   257 VKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKP--VPEQILGKVTVATVNALSYLKDKHGVIHR 319
            .:..|.:::|..:||.||   .|....|:...:|  :.|:.:|.:....:.||..: .|..||||
Yeast    83 TRYYGSYLKDTSLWIIME---HCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCI-HKDNVIHR 143

  Fly   320 DVKPSNILIDERGNIKLCDFGISGRLVDSKANTRS-AGCAAYMAPERIDPKKPKYDIRADVWSLG 383
            |:|.:|:||...||:||||||::.::..:....:: ||...:||||.| .:...||.:.|:||||
Yeast   144 DIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVI-MEGVYYDTKVDIWSLG 207

  Fly   384 ITLVELATARSPYEGCNTD-FEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKY 447
            ||..|:||...||  |:.: ...:..::.|:||.|   |..::|...::|:..||.::.::|...
Yeast   208 ITTYEIATGNPPY--CDVEALRAMQLIIKSKPPRL---EDRSYSTSLKEFIALCLDEDPKERLSA 267

  Fly   448 PELLAQPFIRIYESA-----------------------KVD--VP-------------------- 467
            .:||...|||.:::.                       |::  :|
Yeast   268 DDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAPKPSQNGGGD 332

  Fly   468 -----------------------NW-FQSI-----------------KDNRLRANG--------- 482
                                   .| |.|:                 :||...|..
Yeast   333 EAQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAEDNNEWATAQHDLFNYAY 397

  Fly   483 --------DPTLQRA---TATGSAIGSG-AGSLAGSGSGSAGGAVKYGRA----------TTYAG 525
                    |||....   ...|:.||.| .|::|.:.:.:|.....|..:          |..:|
Yeast   398 PDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNYTNSKYPSKMVAGTTNTSG 462

  Fly   526 QSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGN----GS 586
            .....|..:.|..:..:.:|....|.............|.....:........||...:    ..
Yeast   463 THTAGPMTSSKRLESKAPKQLLELFEDNEIITAENDVNTEAPKISKSISSLNAGNSSRDDFIPSI 527

  Fly   587 GGSGNGSGSSSSASPLSPP-SAGIGDLNRLYRKS----PFMQRKLSNGSHHPHYKYNDESPKKES 646
            ....||:.:::...|..|| |:|    |..|.:|    |.:|.|.:..|..|        |..
Yeast   528 SNEVNGNINNNKMRPHLPPLSSG----NNYYSQSTPALPLLQTKFNKTSKGP--------PTS-- 578

  Fly   647 MFSSIGQSILRNLTTSPFS------QKKHNSTATTIPLPHNNQTLITDAATAAAAAATATTPPNI 705
                       .|||:|.|      ::..||   .:|.|.:...::..:..|.::..||.||.:
Yeast   579 -----------GLTTAPTSIEIEIPEELPNS---ALPTPASADPVLIPSTKARSSTVTAGTPSS- 628

  Fly   706 AATVLTTTPTTTPTWRLPTENSQAYDSCDSSSN----ATTTTLNLGLSSPSPSLPRKQFPTESPT 766
            ::::...:|:..|. ||...|::. :.|.|:..    .:....|.|:||...:.......|:|..
Yeast   629 SSSIQYKSPSNVPR-RLTVSNNRP-EHCPSTITNQKLGSAVASNSGISSTPNNSNNYNNNTDSEN 691

  Fly   767 LQLTS----QQQQQPQRLQPGNQSPIVLQRFYHQQNQL-------REKEAAERYQQQRQQPPVGV 820
            .:.:|    ....|.....|||.:.:...:.......|       ..|.|....|.      :|.
Yeast   692 SRGSSGSNTANSTQMGITNPGNVTKLSTHKASSPSRPLFGVGTSPNRKPAGSPTQN------IGH 750

  Fly   821 TSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAINPASISPS-------SGSGTGNMAGLGIGS 878
            .||   |:|..|||......:|:.:     ..|.:.|.:..||       ||:.:.|:......|
Yeast   751 NST---HTNLAPPPTMKPMANSKDN-----KDILLQPLNSIPSSSTLNTISGNSSNNLTSSNYFS 807

  Fly   879 APASGLGAAGHFGAGGTGEQLQYQPLPIAAEATGTSPTLQSR--SPEQQSDYGGNGNMVASKLSK 941
            ....|....|.|.......:|| .|||        :|.::::  .|...:....||...::.:|.
Yeast   808 NEKEGSRVNGDFKRNNPNLKLQ-MPLP--------TPVVRNKLLDPNTATSQNNNGMPGSAGIST 863

  Fly   942 LYARRQLLGQSSSSGASNSSLDGCSREQHDAGWFNTLAGAMKRQFATYVKTQLNSTAT------- 999
            .....|....:||:.....|:...|.:..|.|      |.:||  :..:..:.||:|:
Yeast   864 NENINQFGFNTSSASNIPVSMTPISEKHIDFG------GKIKR--SQSISNRKNSSASEHPLNIL 920

  Fly  1000 -SPVASSM----------DRDQEPVHPQPPAYRSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSP 1053
             |.|:.::          :.:..|.:..|      ::..:|..:....:.:.|:|||..:.:|:|
Yeast   921 GSSVSGNVSGIGNNNVGSNNNSGPNNSVP------LSANTGNTTIKANSTTIATSSSAAASTTAP 979

  Fly  1054 -TTEPLPGGGTSSFLRRYASSGPG-------GSISTPPSPHILAGLDRRHRSPDPPPRYNRGQSP 1110
             :.:.:|.|...:.:...|::...       |....|.|..:...||.....|....|.:|....
Yeast   980 ISQQTIPSGTQFNHILSSAATAANSVNSLGFGMCPPPQSLQMEMFLDLESFLPGKQRRVDRKPQV 1044

  Fly  1111 LLLRKNLLEL--SGQP 1124
            |...:|||::  .|.|
Yeast  1045 LKELENLLQMFEEGLP 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	85/373 (23%)
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	79/283 (28%)