Protein Alignment hep and MKK2

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_015185.1
• Gene: MKK2 / 855963
• SGDID: S000006061
• Length: 506
• Species: Saccharomyces cerevisiae
• Alignment Length: 479
• Identity: 136/479 - (28%)
• Similarity: 209/479 - (43%)
• Gaps: 111/479 - (23%)

  Fly    46 SARVPPLATSASAATSATHAPSLGAGSV----SGSGISIAQRPA-PPVPHATPF----------- 94
            |....|.:.::::|||.|  .|:.:.|.    ..|..:|..||. ||:|   |.
Yeast    46 SVNESPYSNNSTSATSTT--SSMASNSTLLYNRSSTTTIKNRPVPPPLP---PLVLTQKKDGIEY 105

  Fly    95 ---GSASASSSSSSA------SAFASAAPAT---------------GTFGGTYTPPTTRVSRATP 135
               |.:..|...|:.      ....|:||.:               .|..|..:.|:|.:|
Yeast   106 RVAGDSQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLS---- 166

  Fly   136 TLPMLSSGPGGGLNRTRPVILPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKH- 199
            .....|||....           |...:..:|.:::             |.|:    |::.|:.
Yeast   167 AYDFSSSGSNSA-----------PLSANNIISCSNL-------------IQGK----DVDQLEEE 203

  Fly   200 -------------LGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTG-NAEENKRILMDLDVVLKS 250
                         ||.||.|..|:|.|....:...:.|:|.:.... :.|..|:|..:|. ..||
Yeast   204 AWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQ-FNKS 267

  Fly   251 HDCKYIVKCLGCFV--RDPDVWICMELM-----SMCFDKLLKLSKKPVPEQILGKVTVATVNALS 308
            ....|||:..|.|.  :...::|.||.|     ...:..|||...: :.|:::||:..:.:..||
Yeast   268 FKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR-ISERVIGKIAESVLRGLS 331

  Fly   309 YLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKY 373
            ||.::. |||||:||.|||::|:|.|||||||:||..|:|.|.| ..|.:.|||||||..:  .|
Yeast   332 YLHERK-VIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMT-FTGTSFYMAPERIQGQ--PY 392

  Fly   374 DIRADVWSLGITLVELATARSPYEGCN-----TDFEVLTKVLDSEPPCLPYGE-GYNFSQQFRDF 432
            .:..||||||:||:|:|..|.|:|...     ...|:||.:|...|......| ..::|:.||.|
Yeast   393 SVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSF 457

  Fly   433 VIKCLTKNHQDRPKYPELLAQPFI 456
            :..||.|:.::||...::|..|:|
Yeast   458 IDYCLKKDARERPSPRQMLKHPWI 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	104/304 (34%)
MKK2	NP_015185.1	PKc_Pek1_like	212..499	CDD:270793	100/276 (36%)