Protein Alignment hep and MKK1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_014874.1
• Gene: MKK1 / 854406
• SGDID: S000005757
• Length: 508
• Species: Saccharomyces cerevisiae
• Alignment Length: 491
• Identity: 137/491 - (27%)
• Similarity: 229/491 - (46%)
• Gaps: 89/491 - (18%)

  Fly    24 NESHDQIVLSGARGPVVSGSVPSARVPPLATSASAATSATHA-PSLGAGSVSGSGISIAQRPAPP 87
            :|::..:..:|:.....|...|.    ||.:|.|...|.|.. ||..:.:::    ::.:|||||
Yeast    31 DENNIYLTSNGSSTTAYSSHTPE----PLTSSTSTLFSQTRLHPSDSSMTLN----TMKKRPAPP 87

  Fly    88 ---------------VPHATPFGSAS------------------ASSSSSSASAFASAAPATGTF 119
                           :|...|....|                  :.:|..:.|:.||
Yeast    88 SLPSLSINSQSKCKTLPELVPIADVSDGKHDLGLKQRVIAENELSGNSDLTPSSMAS-------- 144

  Fly   120 GGTYTPPTTRVSRATPTLPM-LSSGPGGG----LNRTRPVILPLPTPPHP-PVSETDMKLKIIME 178
                  |.:..:.::|.|.. ||:..|..    ::.......|:.:...| ..||:.:.|..:.:
Yeast   145 ------PFSHTNTSSPYLRNDLSNSVGSDFSNLISAYEQSSSPIKSSSQPKSSSESYIDLNSVRD 203

  Fly   179 QTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTG-NAEENKRILM 242
             ..:|:.||.:|....:.::.||.||.|..|:|.|....:.:.|.|:|.:.... :.|..|:|..
Yeast   204 -VDQLDENGWKYANLKDRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFR 267

  Fly   243 DLDVVLKSHDCKYIVKCLGCFVRDPD--VWICMELM-----SMCFDKLLKLSKKPVPEQILGKVT 300
            :|. ..:|...:|||:..|.|..|.:  ::|.||.|     ...:..||:...: :.|::|||:.
Yeast   268 ELQ-FNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR-ISEKVLGKIA 330

  Fly   301 VATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPER 365
            .|.:..||||.:|. |||||:||.|||::|.|.:||||||:||..|:|.|.| ..|.:.||||||
Yeast   331 EAVLRGLSYLHEKK-VIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATT-FTGTSFYMAPER 393

  Fly   366 IDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTD--------FEVLTKVLDSEPPCLPYGE- 421
            |..:  .|.:.:||||||:|::|:|..:.|   |:::        ||:|..:|...|......|
Yeast   394 IQGQ--PYSVTSDVWSLGLTILEVANGKFP---CSSEKMAANIAPFELLMWILTFTPELKDEPES 453

  Fly   422 GYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIR 457
            ...:|..|:.|:..||.|:.::||...:::..|:|:
Yeast   454 NIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	102/294 (35%)
MKK1	NP_014874.1	Protein Kinases, catalytic domain	219..506	CDD:473864	98/280 (35%)