Protein Alignment hep and SIK1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_564955.1
• Gene: SIK1 / 843253
• AraportID: AT1G69220
• Length: 836
• Species: Arabidopsis thaliana
• Alignment Length: 665
• Identity: 165/665 - (24%)
• Similarity: 264/665 - (39%)
• Gaps: 143/665 - (21%)

  Fly   128 TRVSRATPTLPMLSSGPGGGLNRTRPVILPLPTPPHPPVSETDMKL-----KIIMEQTGKLNING 187
            |.:.||..:  |..|..||...:..|             |.:..||     :.:.:|..|::...
plant   186 TTMGRAVAS--MQKSNFGGKTRKLDP-------------SSSSSKLHGEDNRKMQQQNSKMSTTS 235

  Fly   188 ------RQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDV 246
                  |:.||  ...:.|.:||.|:.|:|.|...|.::.|:|||.:..|...|..:.|..::::
plant   236 LPDSITREDPT--TKYEFLNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEM 298

  Fly   247 VLKSHDCKY--IVKCLGCFVRDPDVWICMELMSMC----FDKLLKLSKKPVPEQILGKVTVATVN 305
            :   ..|.:  :|:.||.:..:..:||.||   .|    ...|:.::::.:.|..:..:....:.
plant   299 L---QQCNHPNVVRYLGSYQGEDYLWIVME---YCGGGSVADLMNVTEEALEEYQIAYICREALK 357

  Fly   306 ALSYLKDKHGV--IHRDVKPSNILIDERGNIKLCDFGISGRLVD--SKANTRSAGCAAYMAPERI 366
            .|:||   |.:  :|||:|..|||:.|:|.:||.|||::.:|..  ||.|| ..|...:||||.|
plant   358 GLAYL---HSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNT-FIGTPHWMAPEVI 418

  Fly   367 DPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRD 431
              ::.:||.:.|||:||::.:|:|....|....: ...||..:.....|.|...|  .:|..|.|
plant   419 --QENRYDGKVDVWALGVSAIEMAEGLPPRSSVH-PMRVLFMISIEPAPMLEDKE--KWSLVFHD 478

  Fly   432 FVIKCLTKNHQDRPKYPELLAQPFI------------RIYESAKVDVPNWFQ-------SIKD-- 475
            ||.|||||..:.||...|:|...|:            :|.:|.::......|       |::|
plant   479 FVAKCLTKEPRLRPTAAEMLKHKFVERCKTGASAMSPKIEKSRQIRATMALQAQSVVAPSLEDTS 543

  Fly   476 --------------------NRLRANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRA 520
                                |...|....||.|...||:.:      |||.| |..|..:.:|..
plant   544 TLGPKSSEELGITVPSKPPQNSTEAPLTSTLNRQHITGNTV------LAGEG-GDFGTMIVHGED 601

  Fly   521 TTYAGQS---------PTNPQKTIKPTQIPSYQQQQSQFFMQS---ATQLPQTTTTTPTATTNCF 573
            .|....|         .::.|....|.:.|..:...|....:.   |..||...:.:.:...:
plant   602 ETEESDSRSQLVREKESSSSQFEGVPREFPGEELPDSWIHDKKKPPAIDLPVEASISQSMQAS-- 664

  Fly   574 GGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKL------SNGSHH 632
             .|.....:.:...|:....||.:|.|.|...:.|        ||:..:|.||      .|....
plant   665 -SSHEHRTKLHNIAGTQMEGGSDASGSTLKNETVG--------RKAFALQDKLWSIYAAGNTVPI 720

  Fly   633 PHYKYNDESP---KKESMFSSIGQ--------SILRNLTTSPFSQ-KKHNSTATTIPLPHN-NQT 684
            |..:..|.||   ..|:|...:.|        ..|:.|.||...| ||.......:|||.: .|.
plant   721 PFLRATDISPIALLSENMIGGMQQDGNGTVAVEALQELFTSSDPQSKKGRRGQNEMPLPPSVYQR 785

  Fly   685 LITDAATAAAAAATA 699
            |.|.::....|...|
plant   786 LTTSSSLMNLAQVLA 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	94/351 (27%)
SIK1	NP_564955.1	STKc_MAP4K3_like	248..503	CDD:270788	84/269 (31%)