DRSC/TRiP Functional Genomics Resources

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Protein Alignment hep and STK10

DIOPT Version :10

Sequence 1:NP_001368982.1 Gene:hep / 32256 FlyBaseID:FBgn0010303 Length:1294 Species:Drosophila melanogaster
Sequence 2:NP_005981.3 Gene:STK10 / 6793 HGNCID:11388 Length:968 Species:Homo sapiens


Alignment Length:703 Identity:168/703 - (23%)
Similarity:278/703 - (39%) Gaps:145/703 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 RQY--------PTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDL 244
            |:|        |.::.::  :|:||:|..|.|.|..:..:..:.|.|.: .|.:.||.:..::::
Human    21 REYEHVRRDLDPNEVWEI--VGELGDGAFGKVYKAKNKETGALAAAKVI-ETKSEEELEDYIVEI 82

  Fly   245 DVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMC----FDKLLKLSKKPVPEQILGKVTVATVN 305
            : :|.:.|..||||.||.:..|..:||.:|   .|    .|.::....:.:.|..:..|....:.
Human    83 E-ILATCDHPYIVKLLGAYYHDGKLWIMIE---FCPGGAVDAIMLELDRGLTEPQIQVVCRQMLE 143

  Fly   306 ALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRS-AGCAAYMAPERI--- 366
            ||::|..|. :||||:|..|:|:...|:|:|.|||:|.:.:.:.....| .|...:||||.:   
Human   144 ALNFLHSKR-IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207

  Fly   367 DPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCL--PYGEGYNFSQQF 429
            ..|...||.:||:|||||||:|:|....|:...| ...||.|:..|:||.|  |    ..:|.:|
Human   208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELN-PMRVLLKIAKSDPPTLLTP----SKWSVEF 267

  Fly   430 RDFVIKCLTKNHQDRPKYPELLAQPFI----------RIYESAKVDVPNWFQSIKDNRLRANGD- 483
            |||:...|.||.:.||...:||..||:          .:...||.:|   .:.|:|.|.....: 
Human   268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEV---MEEIEDGRDEGEEED 329

  Fly   484 -----PTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSY 543
                 .||:..|...|.:  ...||               .|.....:||:.|   :.|:|   .
Human   330 AVDAASTLENHTQNSSEV--SPPSL---------------NADKPLEESPSTP---LAPSQ---S 371

  Fly   544 QQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNG--------------------------- 581
            |...::...|.:......||:.|..      ..||.||                           
Human   372 QDSVNEPCSQPSGDRSLQTTSPPVV------APGNENGLAVPVPLRKSRPVSMDARIQVAQEKQV 430

  Fly   582 --RGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKK 644
              :|.....:.|.|..:|.:.|.|.....:|.            .||:|||..|..:......|:
Human   431 AEQGGDLSPAANRSQKASQSRPNSSALETLGG------------EKLANGSLEPPAQAAPGPSKR 483

  Fly   645 ESMFSSI----GQSILRNLTTSPFSQKKHNSTATTIPLPHNNQTLITDAATAAAAAATATTPPNI 705
            :|..||:    ......||:|.....|:..|.:...|..:......|..........:.||    
Human   484 DSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITT---- 544

  Fly   706 AATVLTTTPTTTPTWR-LPTENSQAYDSCDSSSNATTTTLN----LGLS------SPSPSLPRKQ 759
             :.:::.........| |..:..:.........:...|.|:    |.|.      ....:..:|.
Human   545 -SKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKF 608

  Fly   760 FPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQQNQLREKEAAERYQQQ 812
            |.||...|:  .||:||.::::   |...|.:|...::.:|.:.....|:|:|
Human   609 FDTELENLE--RQQKQQVEKME---QDHAVRRREEARRIRLEQDRDYTRFQEQ 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hepNP_001368982.1 PKc_MKK7 181..476 CDD:270791 97/315 (31%)
STK10NP_005981.3 STKc_STK10 23..314 CDD:132975 94/303 (31%)
Activation segment 175..224 17/48 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..411 20/102 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..490 16/76 (21%)
PKK 587..725 CDD:463600 18/75 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..690
PKK 755..895 CDD:463600
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 827..865
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..929
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..968
Blue background indicates that the domain is not in the aligned region.

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