Protein Alignment hep and MAP2K7

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_006722863.1
• Gene: MAP2K7 / 5609
• HGNCID: 6847
• Length: 442
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 247/493 - (50%)
• Similarity: 297/493 - (60%)
• Gaps: 84/493 - (17%)

  Fly     8 TIGSRLQSLEAKLQAQN-ESHDQIVLSGARGPVVSGSVPSARVPPLATSASAATSATHAPSLGAG 71
            ::..:|..|||||:.:| |:..:|.|:....|        .|..|:..   ...|...|||
Human     5 SLEQKLSRLEAKLKQENREARRRIDLNLDISP--------QRPRPIIV---ITLSPAPAPS---- 54

  Fly    72 SVSGSGISIAQRPAPPVPHATPFGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPT 136
                      ||.|..:|.|...||.|.||.||....               |||
Human    55 ----------QRAALQLPLANDGGSRSPSSESSPQHP---------------TPP---------- 84

  Fly   137 LPMLSSGPGGGLNRTRP-VILPLPTPPHPPVS----ETDMKLKIIMEQTGKLNINGRQYPTDIND 196
                          .|| .:|.||:....|.|    |.|.||:.||:|||.|.|.|::|..:|||
Human    85 --------------ARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEIND 135

  Fly   197 LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLG 261
            |::||::|:||.|.|.||....:..:||||||||:||.|||||||||||||||||||.|||:|.|
Human   136 LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG 200

  Fly   262 CFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNI 326
            .|:.:.||:|.||||..|.:||.|..:.|:||:||||:|||.|.||.|||:||||||||||||||
Human   201 TFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNI 265

  Fly   327 LIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERI---DPKKPKYDIRADVWSLGITL-- 386
            |:||||.|||||||||||||||||.|||||||||||||||   ||.||.||||||||||||:|
Human   266 LLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPC 330

  Fly   387 -----VELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPK 446
                 |||||.:.||:.|.||||||||||..|||.||...|  ||..|:.||..||||:|:.|||
Human   331 PSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMG--FSGDFQSFVKDCLTKDHRKRPK 393

  Fly   447 YPELLAQPFIRIYESAKVDVPNWFQSI--KDNRLRANG 482
            |.:||...||:.||:.:|||.:||:.:  |....|.:|
Human   394 YNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSG 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	198/306 (65%)
MAP2K7	XP_006722863.1	PKc_MKK7	120..423	CDD:270791	197/304 (65%)