DRSC/TRiP Functional Genomics Resources

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Protein Alignment hep and MAP2K5

DIOPT Version :10

Sequence 1:NP_001368982.1 Gene:hep / 32256 FlyBaseID:FBgn0010303 Length:1294 Species:Drosophila melanogaster
Sequence 2:NP_660143.1 Gene:MAP2K5 / 5607 HGNCID:6845 Length:448 Species:Homo sapiens


Alignment Length:330 Identity:120/330 - (36%)
Similarity:179/330 - (54%) Gaps:24/330 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 PPVSET--DMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVK 226
            |.||::  ...||....:..|:..||:.   :..|:::...||:|..|.|.|..|:.|..|:|||
Human   134 PAVSDSLPSNSLKKSSAELKKILANGQM---NEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVK 195

  Fly   227 QMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPV 291
            .:......|..|:|:.:|:::.|. |..||:...|.|..:..:.||.|.|.   ...|.:.:| :
Human   196 VILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTEFMD---GGSLDVYRK-M 255

  Fly   292 PEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAG 356
            ||.:||::.||.|..|:||.... ::||||||||:|::.||.:||||||:|.:||:|.|.| ..|
Human   256 PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT-YVG 318

  Fly   357 CAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPY------EGCNTDFEVLTKVLDSEPP 415
            ..||||||||..:  :|.|.:|||||||:.:|||..|.||      :|.....::|..::|.:.|
Human   319 TNAYMAPERISGE--QYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSP 381

  Fly   416 CLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPN-WFQSIKDNRLR 479
            .||.||   ||:.|..|:.:|:.|..::||...||:..|||..:......|.: |.....:.|..
Human   382 VLPVGE---FSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRS 443

  Fly   480 ANGDP 484
            ..|.|
Human   444 QQGPP 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hepNP_001368982.1 PKc_MKK7 181..476 CDD:270791 112/301 (37%)
MAP2K5NP_660143.1 PB1_Map2k5 17..107 CDD:99717
Interaction with MAPK7. /evidence=ECO:0000250 18..25
Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000250 64..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..144 3/9 (33%)
Interaction with MAPK7. /evidence=ECO:0000250 117..131
PKc_MKK5 164..442 CDD:132950 109/289 (38%)
Blue background indicates that the domain is not in the aligned region.

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