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Protein Alignment hep and MAP2K1

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	NP_002746.1	Gene:	MAP2K1 / 5604	HGNCID:	6840	Length:	393	Species:	Homo sapiens

Alignment Length:	382	Identity:	126/382 - (32%)
Similarity:	196/382 - (51%)	Gaps:	78/382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 PTP----PHPP------VSETDMKLKIIMEQTGKLNINGRQ------YPTD--------INDLKH 199
            |||    |.|.      .|..:..|:.:.::..:|.::.:|      :.|.        .:|.:.
Human     6 PTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEK 70

  Fly   200 LGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCK--YIVKCLGC 262
            :.:||.|..|.|.|:.|..|..::|.|.:..........:|:.:|.|:   |:|.  |||...|.
Human    71 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGA 132

  Fly   263 FVRDPDVWICMELM-SMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNI 326
            |..|.::.||||.| ....|::||.:.: :||||||||::|.:..|:||::||.::|||||||||
Human   133 FYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI 196

  Fly   327 LIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELAT 391
            |::.||.|||||||:||:|:||.||: ..|..:||:|||:  :...|.:::|:||:|::|||:|.
Human   197 LVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL--QGTHYSVQSDIWSMGLSLVEMAV 258

  Fly   392 ARSPYE-----------GCNTD------------------------------FEVLTKVLDSEPP 415
            .|.|..           ||..:                              ||:|..:::..||
Human   259 GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP 323

  Fly   416 CLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQS 472
            .||.|.   ||.:|:|||.|||.||..:|....:|:...||:..::.:||...|..|
Human   324 KLPSGV---FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCS 377

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.