Protein Alignment hep and fray

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_001303449.2
• Gene: fray / 44233
• FlyBaseID: FBgn0023083
• Length: 707
• Species: Drosophila melanogaster
• Alignment Length: 697
• Identity: 159/697 - (22%)
• Similarity: 254/697 - (36%)
• Gaps: 170/697 - (24%)

  Fly    48 RVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSSSSSASAFASA 112
            :.||:        |....|.....|.|...|:..:||..|.||....|:.:|||.|      .::
  Fly   108 KTPPI--------SKQPRPRNTPRSQSQPAINNRRRPGTPPPHTVAPGNGTASSRS------MTS 158

  Fly   113 APATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPTPPHPPVSETDMKLKIIM 177
            .||.                       |||....|       ...||....||...|
  Fly   159 IPAN-----------------------LSSNNVAG-------AATLPGAAAPPEKYT-------- 185

  Fly   178 EQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILM 242
                        :|...:|.:....:|.|.:..|.....:..|...|:|::    |.|:..   .
  Fly   186 ------------WPNSKDDYELRDVIGVGATAVVHGAYCIPRNEKCAIKRI----NLEKWN---T 231

  Fly   243 DLDVVLKS----HDC--KYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPV-----PEQIL 296
            .:|.:||.    ..|  :.:|.....||...::|:.:.|:.  ...||.:.|..:     .:.:.
  Fly   232 SMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLE--GGSLLDIIKHKMRTSNCKQGVF 294

  Fly   297 GKVTVATV-----NALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRS-- 354
            .:.|:|||     ..|.|. ..:|.||||:|..||||.:.|.|::.|||:|..|...:..:|.
  Fly   295 DEATIATVLKEVLKGLEYF-HSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKV 358

  Fly   355 ----AGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPP 415
                .|...:||||.:: :...||.:||:||.|||.:|:||..:||.. ....:||...|.::||
  Fly   359 RHTFVGTPCWMAPEVME-QDHGYDFKADIWSFGITAIEMATGTAPYHK-YPPMKVLMLTLQNDPP 421

  Fly   416 CLPYG----EGYN-FSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQS--- 472
            .|..|    :.|. :.:.||..:::||.|....||...|||...|.:..:..|.......||
  Fly   422 TLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFKKAKDRKYLTQTLLQSGPS 486

  Fly   473 ----IKDNRLRANGDPTLQRATATGSAIGS-----GAGSLAGSGSGSAGGAVKYGRATTYAGQSP 528
                :.....|..|.......|.||..:.|     ..||..|||:|..    |:..:.:.:...|
  Fly   487 METRVHKAAKRQPGASGRLHRTVTGEWVWSSEEEDNGGSATGSGTGDR----KHPSSDSDSEDRP 547

  Fly   529 TNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGS 593
            .|  :..:.....|.:::.|.....|.:    :.|.||.|.               .:.|:|...
  Fly   548 MN--RLERADSSDSDREEPSPEITHSVS----SATVTPGAP---------------AAAGAGAAQ 591

  Fly   594 GSSSSASPLSPPSAGIGD---LNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFSS-IGQS 654
            ..::..:.|..||...|:   :|.:.|     .|.|....|...:::.......|.:.:. :...
  Fly   592 ELTAGIAQLPLPSEAAGEAPPVNLVLR-----MRNLRRELHDIRFEFVVGKDTAEGIATELVDAG 651

  Fly   655 ILRNLTTSPFSQKKHNSTATTIPLPHNNQTLITDAATAAAAAATATT 701
            ::..|.|.|.:             .|.:|.:        ||:||..|
  Fly   652 LVDALDTQPMA-------------THLDQLI--------AASATMKT 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	87/328 (27%)
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	82/287 (29%)
		OSR1_C	613..670	CDD:463491	11/82 (13%)