Protein Alignment hep and map2k1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_998584.2
• Gene: map2k1 / 406728
• ZFINID: ZDB-GENE-040426-2759
• Length: 395
• Species: Danio rerio
• Alignment Length: 389
• Identity: 129/389 - (33%)
• Similarity: 196/389 - (50%)
• Gaps: 79/389 - (20%)

  Fly   150 RTRPVILPLPTPPHPP------VSETDMKLKIIMEQTGKLNINGRQ------YPTD--------I 194
            |.:|.  |:...|.|.      ...|:..|:.:.::..:|.::.:|      :.|.        .
Zfish     4 RRKPE--PIQLNPIPDGNAINGTGATETNLEALQKKLEELELDEQQKKRLEAFLTQKQKVGELKD 66

  Fly   195 NDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCK--YIV 257
            :|.:.:.:||.|..|.|.|::|..|..|:|.|.:..........:|:.:|.|:   |:|.  |||
Zfish    67 DDFEKISELGAGNGGVVFKVLHRPSGFIMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIV 128

  Fly   258 KCLGCFVRDPDVWICMELM-SMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDV 321
            ...|.|..|.::.||||.| ....|:.||.:.| :||||||||::|.:..||||::||.::||||
Zfish   129 GFYGAFYSDGEISICMENMDGGSLDQCLKKAGK-IPEQILGKVSIAVIKGLSYLREKHKIMHRDV 192

  Fly   322 KPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITL 386
            ||||||::.||.|||||||:||:|:||.||: ..|..:||:|||:  :...|.::.|:||:|::|
Zfish   193 KPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL--QGTHYSVQPDIWSMGLSL 254

  Fly   387 VELATAR----------------SPYEG----CNTD-----------------------FEVLTK 408
            ||:|..|                .|.||    .:|.                       ||:|..
Zfish   255 VEMAIGRFPIPPPDAKELEQIFGQPLEGDPSASDTSPKPRPPGRPGSSYGPDSRPPMAIFELLDY 319

  Fly   409 VLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQS 472
            :::..||.||    ..|..:|:|||.|||.||..:|....:|:...||:..|:.:||...|..|
Zfish   320 IVNEPPPKLP----SIFGAEFQDFVNKCLIKNPAERADLKQLMVHSFIKDSEAEEVDFAGWLCS 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	122/352 (35%)
map2k1	NP_998584.2	PKc_MEK1	63..382	CDD:270816	119/328 (36%)