DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hep and Slik

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	214/934 - (22%)
Similarity:	344/934 - (36%)	Gaps:	231/934 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LGDLGNGTSGNVVKMMHLSSNTIIAVK--QMRRTGNAEENKRILMDLDVVLKSHDCKY--IVKCL 260
            :|:||:|..|.|.|..|.......|.|  |:....|..::   ::::|::   .:.|:  ||:..
  Fly    40 VGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDH---MVEIDIL---SEIKHPNIVELY 98

  Fly   261 GCFVRDPDVWICMELMSMC----FDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDV 321
            ..|..|..:|:   |:..|    .|.::...:||:.|..:..|.......|::| .::.|||||:
  Fly    99 EAFSIDDKLWM---LIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFL-HRNKVIHRDL 159

  Fly   322 KPSNILIDERGNIKLCDFGISGRLVDS-KANTRSAGCAAYMAPE-------RIDPKKPKYDIRAD 378
            |..|:|:...|.:||.|||:|.:...: :.:....|...:||||       |.:|    ||.:.|
  Fly   160 KAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNP----YDHKVD 220

  Fly   379 VWSLGITLVELATARSPYEGCNTD---FEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKN 440
            :|||||||:|||....|    |::   ..||.|:..||||.|.  :...:|::|.||:.|.|.|:
  Fly   221 IWSLGITLIELAQMEPP----NSEMSPMRVLLKIQKSEPPKLE--QPSRWSKEFNDFLKKSLVKD 279

  Fly   441 HQDRPKYPELLAQPFIRIYESAKVDVPNWFQSIKDNRLRANG--------DPTLQ-RATATGSAI 496
            .|.||....|:...||.....||        .|||..|....        |.|.: |.:|....:
  Fly   280 PQVRPTTDVLMQHAFINRNLDAK--------PIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDL 336

  Fly   497 GSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQT 561
            ...:.||.........|             :||:..:..|....||    .|.....:||.....
  Fly   337 DDDSASLQSQDIDKLPG-------------TPTSILRDAKEQSQPS----SSLPIAAAATAAAAA 384

  Fly   562 TTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKL 626
            ||||...|.:          |.|      :....::.|:...||          :.|.|......
  Fly   385 TTTTKATTPD----------RPN------HTKDDNAEAAAQQPP----------HTKVPAPAPPS 423

  Fly   627 SNGSHHPHYKYNDESP---------KKESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLPHNN 682
            |..:..|..:.....|         ||....:::.::     :....|.|||.......|.|.:.
  Fly   424 SQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAET-----SEKTESDKKHFVKKGKAPPPPSP 483

  Fly   683 QTLITDAATAAAAAATATTPPNIAATVLTTTPTTT--------------PTWRLPTENS----QA 729
            ..|    |.|..||:.:.|.|...||...|:|.||              |....||.:|    |:
  Fly   484 LGL----ANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQS 544

  Fly   730 YDSCDSS---SNA----TTTTLNLGLSSPSPS-----LPRKQ---FPTESPTL-QLTSQQQQQP- 777
            ..|..||   |||    :|:.:.:....|:|.     .|:.|   .|....:: |:|......|
  Fly   545 VASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPP 609

  Fly   778 ----QRLQPGNQSPIVLQRFYHQQNQLREKEAAERYQQQRQQPPVGVTSTNPFH----------- 827
                ..:.|.....|::....::...|.|....:.:..  ....:|..:|.|..
  Fly   610 VIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPS--LDDSLGDATTPPHKQSSMILAVNEP 672

  Fly   828 SNYVPPPPSTHSTSS--------QSSTQSTCSQIAINPASISPSSGSGTGNMAGLGIGSAPAS-- 882
            :..||.|||...|||        :|.........|.:.::.:.:|||.:.:.:...:.::..|
  Fly   673 AGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVV 737

  Fly   883 GLGAAGHFGAGGTGEQLQYQPLPIAAEATGTSP----------TLQSRSPEQQSDYGGNGNMVAS 937
            .:|..|......:.|.::.||     ...|..|          ..:.|||:  |....||::...
  Fly   738 TVGDEGVKVKDSSNELVKRQP-----NGVGIVPEDVNIIVNRFKQEKRSPD--SSLSENGSVRGR 795

  Fly   938 KLSKLYARRQLLGQSSSSGASNSSLDGCSREQHDAGWFNTLAGAMKRQFATYVKTQLNSTATSPV 1002
            :..::     |:|.|..|...:...:.....:|:....|      |:|:              |.
  Fly   796 RGIEV-----LVGGSGGSDVDSIGTNTSQESRHETDHNN------KQQY--------------PA 835

  Fly  1003 ASSMDRDQEPVHPQPPAYRSVVNN 1026
            |:.|        |.||.  |:.||
  Fly   836 AALM--------PPPPP--SLTNN 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	90/294 (31%)
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	91/297 (31%)
		S_TKc	37..295	CDD:214567	84/274 (31%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910