DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hep and Map2k7

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	NP_001036022.1	Gene:	Map2k7 / 26400	MGIID:	1346871	Length:	468	Species:	Mus musculus

Alignment Length:	555	Identity:	257/555 - (46%)
Similarity:	315/555 - (56%)	Gaps:	107/555 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TIGSRLQSLEAKLQAQN-ESHDQIVLSGARGPVVSGSVPSARVPPLATSASAATSATHAPSLGAG 71
            ::..:|..|||||:.:| |:..:|.|:....|        .|..|:..   ...|...|||
Mouse     5 SLEQKLSRLEAKLKQENREARRRIDLNLDISP--------QRPRPIIV---ITLSPAPAPS---- 54

  Fly    72 SVSGSGISIAQRPAPPVPHATPFGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPT 136
                      ||.|..:|.|...||.|.||.||....               |||
Mouse    55 ----------QRAALQLPLANDGGSRSPSSESSPQHP---------------TPP---------- 84

  Fly   137 LPMLSSGPGGGLNRTRP-VILPLPTPPHPPVS----ETDMKLKIIMEQTGKLNINGRQYPTDIND 196
                          ||| .:|.||:....|.|    |.|.||:.||:|||.|.|.|::|..:|||
Mouse    85 --------------TRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEIND 135

  Fly   197 LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLG 261
            |::||::|:||.|.|.||....:..|||||||||:||.|||||||||||||||||||.|||:|.|
Mouse   136 LENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG 200

  Fly   262 CFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNI 326
            .|:.:.||:|.||||..|.:||.|..:.|:||:||||:|||.|.||.|||:||||||||||||||
Mouse   201 TFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNI 265

  Fly   327 LIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERI---DPKKPKYDIRADVWSLGITLVE 388
            |:||||.|||||||||||||||||.|||||||||||||||   ||.||.||||||||||||:|||
Mouse   266 LLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVE 330

  Fly   389 LATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQ 453
            |||.:.||:.|.||||||||||..|||.||...|  ||..|:.||..||||:|:.||||.:||..
Mouse   331 LATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMG--FSGDFQSFVKDCLTKDHRKRPKYNKLLEH 393

  Fly   454 PFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYG 518
            .||:.||..:|||.:||:.:                             :|.:.|....|.:...
Mouse   394 SFIKHYEILEVDVASWFKDV-----------------------------MAKTESPRTSGVLSQH 429

  Fly   519 RATTYAG---QSPTNPQKTIKPTQIPSYQQQQSQF 550
            ....::|   :|||:|.........|:..|.|:::
Mouse   430 HLPFFSGSLEESPTSPPSPKSFPLSPAIPQAQAEW 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	198/297 (67%)
Map2k7	NP_001036022.1	D domain. /evidence=ECO:0000250	37..73		14/52 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..93		15/68 (22%)
		PKc_MKK7	120..416	CDD:270791	198/326 (61%)
		S_TKc	137..396	CDD:214567	180/260 (69%)
		DVD domain. /evidence=ECO:0000250	393..416		9/51 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I976
eggNOG	1	0.900	-	-		E1_KOG0983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56548
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1923
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	1	1.000	-	-		FOG0005845
OrthoInspector	1	1.000	-	-		oto93687
orthoMCL	1	0.900	-	-		OOG6_107093
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3854
SonicParanoid	1	1.000	-	-		X4836
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.660