Protein Alignment hep and Map2k6

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_036012601.1
• Gene: Map2k6 / 26399
• MGIID: 1346870
• Length: 347
• Species: Mus musculus
• Alignment Length: 319
• Identity: 145/319 - (45%)
• Similarity: 199/319 - (62%)
• Gaps: 20/319 - (6%)

  Fly   160 TPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIA 224
            |||.    :.|.|..|        :|..:.:....:||:.:.:||.|..|.|.||.|:.|..|:|
Mouse    41 TPPR----DLDSKACI--------SIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMA 93

  Fly   225 VKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLK--LS 287
            ||::|.|.|::|.||:||||||.:::.||.:.|...|...|:.|||||||||....||..|  :.
Mouse    94 VKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID 158

  Fly   288 K-KPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKAN 351
            | :.:||.||||:.|:.|.||.:|..|..||||||||||:||:..|.:|:|||||||.||||.|.
Mouse   159 KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAK 223

  Fly   352 TRSAGCAAYMAPERIDPK--KPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEP 414
            |..|||..|||||||:|:  :..|.:::|:||||||::|||..|.||:...|.|:.|.:|::...
Mouse   224 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 288

  Fly   415 PCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQSI 473
            |.||..:   ||..|.||..:||.||.::||.||||:..||..::||...||.::.:.|
Mouse   289 PQLPADK---FSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVKLI 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	139/298 (47%)
Map2k6	XP_036012601.1	PKc_MKK3_6	64..346	CDD:173729	138/284 (49%)