DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hep and wis1

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	NP_595457.1	Gene:	wis1 / 2541055	PomBaseID:	SPBC409.07c	Length:	605	Species:	Schizosaccharomyces pombe

Alignment Length:	566	Identity:	172/566 - (30%)
Similarity:	257/566 - (45%)	Gaps:	111/566 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STIEFETIGSRLQSLEAKLQAQNESHDQIVLSGAR----GPVVSGSVPSARVPPLATSASAAT-- 60
            |:...::.||.|.||.....:....:|..|.|.:|    .|.:..:||:.|:....:|.|..:
pombe    40 SSSNTDSSGSSLGSLSLNSNSSGSDNDSKVSSPSREIPSDPPLPRAVPTVRLGRSTSSRSRNSLN 104

  Fly    61 ----SATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSAS----------ASSSSSSASAFAS 111
                ..:..|.....:.:|.. :|...|.||.|.  |.|.::          ||.|.|.......
pombe   105 LDMKDPSEKPRRSLPTAAGQN-NIGSPPTPPGPF--PGGLSTDIQEKLKAFHASRSKSMPEVVNK 166

  Fly   112 -AAPATGTFG----GTYTPPTT----RVSRA---TPTLPMLSSGPGGGLNRTRPVILPLPT---- 160
             ::|.|...|    |:|..|.:    |:|.:   :|.:|  .||....|...|..:|..||
pombe   167 ISSPTTPIVGMGQRGSYPLPNSQLAGRLSNSPVKSPNMP--ESGLAKSLAAARNPLLNRPTSFNR 229

  Fly   161 -------PPH--------------------------PP-----VSET----------------DM 171
                   ||.                          ||     ||||                :.
pombe   230 QTRIRRAPPGKLDLSNSNPTSPVSPSSMASRRGLNIPPTLKQAVSETPFSTFSDILDAKSGTLNF 294

  Fly   172 KLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEE 236
            |.|.::...|....:|..:..:::::..|.:||.|..|.|.|.:|..:...:|:|::|.:.....
pombe   295 KNKAVLNSEGVNFSSGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEAT 359

  Fly   237 NKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSM-CFDKLLKLSKKPVPEQILGKVT 300
            ..:|:|:||::.|:.. .|||...|.|..:..|:||||.|.. ..|||.....|  .|.:|.:..
pombe   360 FNQIIMELDILHKAVS-PYIVDFYGAFFVEGSVFICMEYMDAGSMDKLYAGGIK--DEGVLARTA 421

  Fly   301 VATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPER 365
            .|.|..|..||::|.:|||||||:|:|::..|.:||||||:||.||.|.:.| :.||.:||||||
pombe   422 YAVVQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKT-NIGCQSYMAPER 485

  Fly   366 IDPKKP-----KYDIRADVWSLGITLVELATARSPY--EGCNTDFEVLTKVLDSEPPCLPYGEGY 423
            |....|     .|.::|||||||:|::|:|....||  |...:.|..|:.:.|.:||.||    .
pombe   486 IRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLP----D 546

  Fly   424 NFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNW 469
            :||.:.||||.|||.||...||.|.||...|::..|::|.||:.:|
pombe   547 SFSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDMASW 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	116/297 (39%)
wis1	NP_595457.1	PKc_PBS2_like	318..600	CDD:132953	114/283 (40%)
wis1	NP_595457.1	S_TKc	322..579	CDD:214567	109/264 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000