DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hep and Map2k5

DIOPT Version :10

Sequence 1:NP_001368982.1 Gene:hep / 32256 FlyBaseID:FBgn0010303 Length:1294 Species:Drosophila melanogaster
Sequence 2:NP_035970.1 Gene:Map2k5 / 23938 MGIID:1346345 Length:448 Species:Mus musculus


Alignment Length:353 Identity:123/353 - (34%)
Similarity:182/353 - (51%) Gaps:40/353 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 SGPGGGLNRTRPVI---LPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDL 203
            :||.   ..|.||:   ||            ...||....:..|:..||:.   :..|:::...|
Mouse   126 AGPS---QHTSPVVSDSLP------------SNSLKKSSAELRKILANGQM---NEQDIRYRDTL 172

  Fly   204 GNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPD 268
            |:|..|.|.|..|:.|..|:|||.:......|..|:|:.:|:::.|. |..||:...|.|..:..
Mouse   173 GHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENR 236

  Fly   269 VWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGN 333
            :.||.|.|.   ...|.:.:| :||.:||::.||.|..|:||.... ::||||||||:|::..|.
Mouse   237 ISICTEFMD---GGSLDVYRK-IPEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTGGQ 296

  Fly   334 IKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPY-- 396
            :||||||:|.:||:|.|.| ..|..||||||||..:  :|.|.:|||||||:.:|||..|.||  
Mouse   297 VKLCDFGVSTQLVNSIAKT-YVGTNAYMAPERISGE--QYGIHSDVWSLGISFMELALGRFPYPQ 358

  Fly   397 ----EGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI- 456
                :|.....::|..::|.:.|.||.||   ||:.|..|:.:|:.|..::||...||:..||| 
Mouse   359 IQKNQGSLMPLQLLQCIVDEDSPVLPLGE---FSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420

  Fly   457 RIYESAKVDVPNWFQSIKDNRLRANGDP 484
            :..:.....|..|.....:.|....|.|
Mouse   421 QFNDGNSTVVSMWVCRALEERRSQQGPP 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hepNP_001368982.1 PKc_MKK7 181..476 CDD:270791 111/301 (37%)
Map2k5NP_035970.1 PB1_Map2k5 17..107 CDD:99717
Interaction with MAPK7. /evidence=ECO:0000269|PubMed:16507987 18..25
Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000269|PubMed:12813044, ECO:0000269|PubMed:16507987 64..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..144 7/32 (22%)
Interaction with MAPK7. /evidence=ECO:0000269|PubMed:16507987 117..131 2/7 (29%)
PKc_MKK5 164..442 CDD:132950 108/289 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.