Protein Alignment hep and sek-5

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_508916.3
• Gene: sek-5 / 185267
• WormBaseID: WBGene00018034
• Length: 360
• Species: Caenorhabditis elegans
• Alignment Length: 366
• Identity: 110/366 - (30%)
• Similarity: 171/366 - (46%)
• Gaps: 58/366 - (15%)

  Fly   156 LPLPTPPHPPVSETDMKLKIIMEQ--TGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLS 218
            :|.|....||:.||   :..:::.  .|.:.::||......|.|.....:|||...:.|..:..:
 Worm     9 MPRPKLDLPPLRET---IPEVLKNGALGYICVSGRILSVPENLLYGGERIGNGEGQSAVYRLIYN 70

  Fly   219 SNTI----IAVKQMRRTGNAEENK---RILMDLDVVLKSHDCKYIVKCLGCFV---RD-PDVWIC 272
            ...|    :||:..:.......||   :.|.:::|:.....|.:||...|.:|   || ..:.|.
 Worm    71 GKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIF 135

  Fly   273 MELMSMCFDKLLKLSKK---PVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNI 334
            ||.|::....|...:.|   .:||.::|::..:.::|:.:|||:..:||||:||.|||||..|.:
 Worm   136 MEEMALSASVLKTEALKQGGAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRV 200

  Fly   335 KLCDFGISGRLVDSKANTRSAGCAAYMAPERI---DPKKPKYDIRADVWSLGITLVELATARSPY 396
            |:|||||.|.|.:|.| ....||..|.|||.:   ....|.|.|::|:||||||:.||||.|.||
 Worm   201 KICDFGICGILENSIA-VSDTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPY 264

  Fly   397 EGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYES 461
            ....::|.:|:.::.:..|.|..|   .:|....:||.|.|.....|||.
 Worm   265 PVGFSEFTLLSAIVTTPAPYLERG---TYSDSLVEFVSKLLQIKEADRPS--------------- 311

  Fly   462 AKVDVPNWFQSIKDNRLRANGD-PTLQRATATGSAIGSGAG 501
                    ..::||.:...|.| |.|        .||:|.|
 Worm   312 --------IVAVKDLQFFLNNDTPFL--------CIGTGVG 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	95/311 (31%)
sek-5	NP_508916.3	Protein Kinases, catalytic domain	58..311	CDD:473864	86/256 (34%)