Protein Alignment hep and mek-1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_001024771.1
• Gene: mek-1 / 181004
• WormBaseID: WBGene00003185
• Length: 347
• Species: Caenorhabditis elegans
• Alignment Length: 343
• Identity: 159/343 - (46%)
• Similarity: 221/343 - (64%)
• Gaps: 16/343 - (4%)

  Fly   140 LSSGPGGGLNRT--RPVI--LPLPTPPHPPVSETDMKLKIIMEQ----TGKLNINGRQYPTDIND 196
            |..|..|||...  .|::  :|.|.|.||..|..|..:|.:|:|    :|.|.:.|.:...|:.:
 Worm     7 LGMGRPGGLGGLGGEPIMQQMPQPAPHHPSRSSNDHNVKNLMKQAEENSGYLTLQGNRRKADLKE 71

  Fly   197 LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLG 261
            |:.:.|:|:|:.|.|.|..:.|  .|:|||.|.||.|:.|..||||||||:..|.||.|||:|.|
 Worm    72 LQFVEDIGHGSCGTVTKCRYKS--VIMAVKTMPRTSNSYEMSRILMDLDVICLSFDCPYIVRCFG 134

  Fly   262 CFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNI 326
            .|:.:.||.:|||.|:.|.|:||...|:|:||:|:||::|:.:.||.|||.||.::|||||||||
 Worm   135 YFITNFDVRVCMECMATCLDRLLIRIKQPIPERIIGKLSVSIIKALHYLKTKHQIMHRDVKPSNI 199

  Fly   327 LIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKK-PKYDIRADVWSLGITLVELA 390
            |:|..|.||||||||:|||::|:|:::.|||..||.|||:||.. ..||||:||||.|:||||||
 Worm   200 LLDWSGVIKLCDFGIAGRLIESRAHSKQAGCPLYMGPERLDPNNFDSYDIRSDVWSFGVTLVELA 264

  Fly   391 TARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPF 455
            |.:.||.|  |:|::::|:|:.|||.|   :...||..|...|..||.::...||.|..||..||
 Worm   265 TGQYPYAG--TEFDMMSKILNDEPPRL---DPAKFSPDFCQLVESCLQRDPTMRPNYDMLLQHPF 324

  Fly   456 IRIYESAKVDVPNWFQSI 473
            :..:|..:.||..||..:
 Worm   325 VVHHEKIETDVEEWFADV 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	143/294 (49%)
mek-1	NP_001024771.1	PKc_MKK7	56..345	CDD:270791	143/294 (49%)