Protein Alignment hep and cst-1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_001024575.2
• Gene: cst-1 / 180708
• WormBaseID: WBGene00017472
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 495
• Identity: 134/495 - (27%)
• Similarity: 213/495 - (43%)
• Gaps: 77/495 - (15%)

  Fly   191 PTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDC-- 253
            |.::.|:  :|.||.|:.|:|.|.:|..|..::|:|::....:.:|   |:.::.::   ..|
 Worm    31 PEEVFDI--VGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQE---IIKEISIM---QQCKS 87

  Fly   254 KYIVKCLGCFVRDPDVWICMELMSM-CFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVI 317
            ||:||..|.:.:..|:||.||.... ....:::..:||:.||.:..|...|:..|.||.|.. .|
 Worm    88 KYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLK-KI 151

  Fly   318 HRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSA-GCAAYMAPERIDPKKPKYDIRADVWS 381
            |||:|..|||::..|..||.|||::|:|.|:.|...:. |...:||||.|:  :..||.:||:||
 Worm   152 HRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE--EIGYDTKADIWS 214

  Fly   382 LGITLVELATARSPYEGCN---TDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQD 443
            ||||.:|:|..|.||...:   ..|.:.||    .||.....|  .:|.:|.||:..||.|..::
 Worm   215 LGITAIEMAEGRPPYSDIHPMRAIFMIPTK----PPPTFKKPE--EWSSEFNDFIRSCLIKKPEE 273

  Fly   444 RPKYPELLAQPFIRIYESAKVDVPNWFQSIKDNRLRANGDPTLQR--ATATGSAIGSGAGSLAGS 506
            |.....|....||:                     .|.|...:|.  ..|...|| .|...:|.|
 Worm   274 RKTALRLCEHTFIK---------------------NAPGCDIMQLMIQDAQEKAI-LGQAPMAAS 316

  Fly   507 GSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTN 571
             ||:....:..|.:|...|...|..|.  |...:.:...:.....::...::|::....
 Worm   317 -SGNDATLLSEGMSTMIDGGESTLVQH--KDNYVTAQSLRSQMESLRIGGEIPKSAYIP------ 372

  Fly   572 CFGGSGNGNG-RGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKLSNGSH-HPH 634
              |.|.|||. |....|.:.:.|..|.: .|.:....|           |..|...|..|: ...
 Worm   373 --GSSKNGNSPRVQPPGHTASASDPSKN-QPFAQDGTG-----------PNFQLGTSESSYKDAS 423

  Fly   635 YKYNDESPKKESMFSSI---GQ-SILRNLTTSPFSQKKHN 670
            |...:...:.|:.|...   |. ..|||:|.....::|.:
 Worm   424 YNMMNTEAEYENRFQRAVVDGDFEFLRNITLDELIRRKES 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	92/291 (32%)
cst-1	NP_001024575.2	STKc_MST1_2	31..286	CDD:132943	90/271 (33%)
		Mst1_SARAH	446..493	CDD:463314	5/18 (28%)