Protein Alignment hep and gck-1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_505310.2
• Gene: gck-1 / 179274
• WormBaseID: WBGene00001526
• Length: 803
• Species: Caenorhabditis elegans
• Alignment Length: 753
• Identity: 185/753 - (24%)
• Similarity: 297/753 - (39%)
• Gaps: 156/753 - (20%)

  Fly    86 PPVPHATPFGSASASSSSSSASAFASAAPATG--------TFGGTYTPPTTRVSRATPTLPMLSS 142
            ||..|.| :|..:.|....|..:.......||        |..|.|.  :|...:.||.:.:.||
 Worm    84 PPREHVT-YGIMNDSKMDDSIDSATLNRFETGFKPSNFGKTIQGIYN--STEHPQQTPEVVLPSS 145

  Fly   143 GPGGGLNRTRPVILPLPTPPHPPVSETDMKLKII--MEQTGKLNINGRQYPTDINDLKHLGDLGN 205
                 |:....|:.|..:||.|.     .:.|::  :|...||:      |..|...:.  .:|.
 Worm   146 -----LSVDLNVMSPEVSPPKPA-----ERRKVVKPIEDNSKLD------PEVIFTKQE--RIGR 192

  Fly   206 GTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVW 270
            |:.|.|.|.:...:..::|:|.:......:|.:.|..::. ||...|.:|:.|..|.|::...:|
 Worm   193 GSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLW 256

  Fly   271 ICMELMSMCFDKLLKLSKK-PVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNI 334
            |.||.:.  ....|.|:|. .:.|..:..:....:..|.||..:. .||||:|.:|:|:.|.|::
 Worm   257 IIMEYLG--GGSALDLTKSGKLDESHIAVILREILKGLEYLHSER-KIHRDIKAANVLVSEHGDV 318

  Fly   335 KLCDFGISGRLVDS-KANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEG 398
            |:.|||::|:|.:: |......|...:||||.|  |:..||.:||:||||||.:|||....|:..
 Worm   319 KVADFGVAGQLTETVKKRITFVGSPFWMAPELI--KQSSYDYKADIWSLGITAIELANGEPPHSD 381

  Fly   399 CNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIR------ 457
            .: ...||..:..:.||.|   :|..:|:.|::||..||.|:.::||....||...||:
 Worm   382 LH-PMRVLFLIPKNPPPVL---QGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNS 442

  Fly   458 -----------------IYESAKVD--------VPNW-FQSIKDNRLRANGDPTLQRAT------ 490
                             :...:.:|        ...| :.:::..|:.|:.|.|:::.|
 Worm   443 ILVDLIERAAEYRLRTGVSSDSDLDEDSDGGGGTSKWDYPTVRGPRVSADDDGTVRQRTDRPRAQ 507

  Fly   491 --------ATGSAIGSGA------------GSLAGSGSGSAGGAV--KY-------------GRA 520
                    :.|..|..|:            .|:..||.||.|.:.  :|             |.|
 Worm   508 VDRRSPSGSPGGTIVRGSPQVAAVAEQLRNSSVGSSGYGSGGNSASSQYATSSLPQSHTASSGGA 572

  Fly   521 TTYAGQSPT-NPQKTIKPTQ---IPSYQQQQSQFFMQ------------SATQLPQTTTTTPTAT 569
            ||....||. :|..::..||   .||.|:..|....:            |:...|.......|::
 Worm   573 TTITLGSPNGSPTSSLARTQSMVSPSGQRSGSAQSWELERGNRPMSERVSSQVSPSKYNQHRTSS 637

  Fly   570 TN-CFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSP------PSAGIGDLNRLYRKSPFMQRKLS 627
            :| ..||||......||||...||:.|:.:.|..|.      |....|.|:  ||:|........
 Worm   638 SNGVQGGSGGRREYINGSGSGLNGNSSNQNHSEYSDAVRQRGPGGSGGRLD--YRESHVPTSSQE 700

  Fly   628 NGSHHPHYKYNDESPKKE---------------SMFSSIGQSILRNLTTSPFSQKKHNSTATTIP 677
            |.:|...|.|....|.:|               |:..:|.........|:...|.:|........
 Worm   701 NLNHGRMYGYGAPPPSREANNVPMPRVKGALDCSLLPAIEHLSRTRHATAALDQLRHVFRDVEDS 765

  Fly   678 LPHNNQTLITDAATAAAAAATATTPPNIAATVLTTTPT 715
            .|.....||.:.....|....:.:..:.|...|||.|:
 Worm   766 CPGICNELIEELMQRIAVPQVSQSDLDAAIRRLTTPPS 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	89/328 (27%)
gck-1	NP_505310.2	STKc_MST3_like	183..455	CDD:270786	84/283 (30%)