Protein Alignment hep and Map2k1

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_113831.1
• Gene: Map2k1 / 170851
• RGDID: 70495
• Length: 393
• Species: Rattus norvegicus
• Alignment Length: 382
• Identity: 126/382 - (32%)
• Similarity: 196/382 - (51%)
• Gaps: 78/382 - (20%)

  Fly   159 PTP----PHPP------VSETDMKLKIIMEQTGKLNINGRQ------YPTD--------INDLKH 199
            |||    |.|.      .|..:..|:.:.::..:|.::.:|      :.|.        .:|.:.
  Rat     6 PTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEK 70

  Fly   200 LGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCK--YIVKCLGC 262
            :.:||.|..|.|.|:.|..|..::|.|.:..........:|:.:|.|:   |:|.  |||...|.
  Rat    71 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGA 132

  Fly   263 FVRDPDVWICMELM-SMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNI 326
            |..|.::.||||.| ....|::||.:.: :||||||||::|.:..|:||::||.::|||||||||
  Rat   133 FYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI 196

  Fly   327 LIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELAT 391
            |::.||.|||||||:||:|:||.||: ..|..:||:|||:  :...|.:::|:||:|::|||:|.
  Rat   197 LVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL--QGTHYSVQSDIWSMGLSLVEMAV 258

  Fly   392 ARSPYE-----------GCNTD------------------------------FEVLTKVLDSEPP 415
            .|.|..           ||..:                              ||:|..:::..||
  Rat   259 GRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP 323

  Fly   416 CLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQS 472
            .||.|.   ||.:|:|||.|||.||..:|....:|:...||:..::.:||...|..|
  Rat   324 KLPSGV---FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCS 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	119/350 (34%)
Map2k1	NP_113831.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		6/20 (30%)
		PKc_MEK1	62..380	CDD:270816	116/326 (36%)
		RAF1-binding	270..307		2/36 (6%)