Protein Alignment hep and LOC1281255

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_061498882.1
• Gene: LOC1281255 / 1281255
• VectorBaseID: AGAMI1_014136
• Length: 1172
• Species: Anopheles gambiae
• Alignment Length: 1280
• Identity: 489/1280 - (38%)
• Similarity: 623/1280 - (48%)
• Gaps: 304/1280 - (23%)

  Fly    93 PFGSASASS-SSSSASAFASAAPATGTFGG-------TYTPPTTRVSRATP--TLPMLSSGPGGG 147
            |.|:..|:: |...||........|.|..|       |......:..|:||  :||:.:..|...
Mosquito     3 PTGTHPATAPSDGRASEVGKNGSTTATMSGSSIDNRITMMEQMIQNPRSTPSLSLPISTQPPANR 67

  Fly   148 LNRT---------RPVI-LPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGD 202
            .|||         ||.: |.||.......||:::|.:.|::::|.|.||.:.|.|.::||:.||:
Mosquito    68 FNRTGSGGMGGPNRPSLGLNLPIVSGTRRSESELKFQKIVDKSGLLKINDKIYRTQLSDLEDLGE 132

  Fly   203 LGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDP 267
            |||||||:||||.|..|..||||||||||||.||||||:|||||||||.:|||||||||||:.|.
Mosquito   133 LGNGTSGHVVKMRHNPSGAIIAVKQMRRTGNDEENKRIIMDLDVVLKSENCKYIVKCLGCFITDA 197

  Fly   268 DVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERG 332
            |||||||||:.|||||.|.|||||||:||||||||||.||:||||.|.||||||||||||||:||
Mosquito   198 DVWICMELMTTCFDKLQKKSKKPVPEEILGKVTVATVRALAYLKDNHRVIHRDVKPSNILIDDRG 262

  Fly   333 NIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYE 397
            ||||||||||||||||.|.|||||||||||||||||.|..|||||||||||||||||||...||.
Mosquito   263 NIKLCDFGISGRLVDSNARTRSAGCAAYMAPERIDPAKTVYDIRADVWSLGITLVELATGVFPYR 327

  Fly   398 GCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI-RIYES 461
            ||.|||||||:||.|.||.||  |..|||.:|||||..||.|::|.|||||:||...|: |....
Mosquito   328 GCVTDFEVLTQVLTSNPPRLP--EDQNFSPEFRDFVQLCLQKDYQARPKYPDLLRHAFLQRAEHD 390

  Fly   462 AKVDVPNWFQSIKDN---RLRANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTY 523
            ..::|..||:::..|   :|.:...|    .||..||..|...:...|...:        |..|.
Mosquito   391 TTINVGEWFRNVAVNCGIQLTSTPPP----PTAGSSASVSSPPTWTASSEQT--------RIPTP 443

  Fly   524 AG------QSPTNPQK---TIKPTQIP--------------------SYQQQQSQFFMQSATQLP 559
            .|      |:.:|.||   .|..:.||                    |..||:||..:....||.
Mosquito   444 LGSLTEVVQAQSNQQKQTIAIAASSIPIKSTATILSPHIANEAPSNLSDLQQRSQHELNQQQQLL 508

  Fly   560 QT-----TTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSA---------SP-------LS 603
            |:     :..:.:::|:....:..|:.....|..:...|.|::.|         ||       :.
Mosquito   509 QSKLSNISLASSSSSTSAAAAAAAGSTPVPASSYTPTSSSSAAGAGAFDTRRSPSPQAYYLAKMQ 573

  Fly   604 PPSA-------------------GIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFS 649
            |.||                   |..:..|.|:.|||:.|:.::       :|.:.||||||..|
Mosquito   574 PKSAITSTSVPIASGGGPAFERNGSLEPARKYKHSPFLSRRTAS-------EYGNGSPKKESTLS 631

  Fly   650 SIGQSILRNLTTSPFSQKKHNSTATTIPLPHNNQTLITDAATAAAAAATATTPPNIAATVLTTTP 714
            |:||||.:|||||||:|:|                               :.||  ..:.|...|
Mosquito   632 SLGQSIFKNLTTSPFAQRK-------------------------------SLPP--GESKLAYPP 663

  Fly   715 TTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLT------SQQ 773
            ..:|: .:|..::..|.:......|....:.   ||||           ||.|.|.      |:.
Mosquito   664 PASPS-PMPVASATIYANGGGGGGAGAGGMG---SSPS-----------SPLLLLRKAHHDGSET 713

  Fly   774 QQQPQRLQPGNQSPIVLQRFYHQQNQLRE----------------KEAAERYQQQRQQPPVGVTS 822
            :.|.:.|. ||.|||||||||||||||:|                ::..:::|||:||...|.:|
Mosquito   714 ETQYKHLH-GNTSPIVLQRFYHQQNQLKEQQREALQQHHHHQQQQQQQQQQHQQQQQQVIYGYSS 777

  Fly   823 TNPFHS---------NYVPPPP------STHSTSSQSSTQSTCSQIAI------NPAS-ISPSSG 865
            .:|..|         .|.|.|.      ..|...|.:...:|..|.||      .||: ::||..
Mosquito   778 PSPIPSASEASPRPIRYSPLPSHRTVHHGVHPVLSNTGGTTTLHQSAIPLYKHHEPAAPLAPSQP 842

  Fly   866 SGTGNMAGLGIGSAPASGLGAAGHFG----AGGTGEQLQYQPLPIAAEATGTSPTLQSRSPEQQS 926
            ||..........|...........|.    :||.|:::      |....|...||:.|.:.: :|
Mosquito   843 SGIPVYQQQTTASPKHKSSSFFNTFSRGMKSGGRGDKV------IDRGGTAAPPTMMSGAAD-RS 900

  Fly   927 DYGGNGNMVASKLSKLYARRQ---------------LLGQSSSSGASNSSLDGCSREQHDAGWFN 976
            .|.|......:..:.||....               |.|.|:..|...:.|......:.||||||
Mosquito   901 LYAGTTTTNTTHQTALYQHHHQGQPNTSSMLHRHGALSGISNGGGGGGAGLAMPEGSKEDAGWFN 965

  Fly   977 TLAGAMKRQFATYVKTQL--NSTATSPVASSMDRD-----------------------QEPVHPQ 1016
            :.|. :||:||::||..|  |.|..|...::...|                       |:..|.|
Mosquito   966 SFAD-IKRKFASFVKLNLSNNVTGASGTGTTTAGDRLTLKEKHLQQQQLLQQQQQFLLQQQQHQQ 1029

  Fly  1017 PPAYRSVVNNG--SGGKSYYYRTLSAASSSSNTSQSTSPTTEPLPGGGTSSFLRRYASSGPGGSI 1079
            .....|...:|  :||....|                  ...|.|.||:|:           .||
Mosquito  1030 QHYVSSNPFDGMTAGGMGGVY------------------GAGPYPSGGSSA-----------ASI 1065

  Fly  1080 STPPS-----PHIL--AGLDRRHRSPDPPPRYNRGQSPLLLRKNLLELSGQPPGSPLLHRR---Y 1134
            ..|||     .|:|  ...||||||||||||.|||||||||::.|.:|.  ..||||::||   .
Mosquito  1066 VQPPSAIPQLAHVLNSPATDRRHRSPDPPPRLNRGQSPLLLQRKLEQLG--HTGSPLMNRRPFNS 1128

  Fly  1135 VSASPPLPPPRRGSESVPGSPQHFRTRIHYTPEPQRRIYR-TIDQ 1178
            .|.|||| ||||.|||.||||||.|.||:|||||.||.|. ||:|
Mosquito  1129 TSPSPPL-PPRRASESAPGSPQHLRARINYTPEPHRRPYHTTIEQ 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	214/295 (73%)
LOC1281255	XP_061498882.1	None