DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hep and Map2k6

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	NP_446155.1	Gene:	Map2k6 / 114495	RGDID:	620666	Length:	334	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	144/332 - (43%)
Similarity:	204/332 - (61%)	Gaps:	11/332 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GLNRTRPVILPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNV 211
            |..|...:.:|......|..|.|..:   .::....::|..:.:....:||:.:.:||.|..|.|
  Rat     6 GKKRNPGLKIPREAFEQPQTSSTPPR---DLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVV 67

  Fly   212 VKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELM 276
            .||.|:.|..|:|||::|.|.|::|.||:||||||.:::.||.:.|...|...|:.|||||||||
  Rat    68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELM 132

  Fly   277 SMCFDKLLK--LSK-KPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCD 338
            ....||..|  :.| :.:||.||||:.|:.|.||.:|..|..||||||||||:||:..|.:|:||
  Rat   133 DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCD 197

  Fly   339 FGISGRLVDSKANTRSAGCAAYMAPERIDPK--KPKYDIRADVWSLGITLVELATARSPYEGCNT 401
            |||||.||||.|.|..|||..|||||||:|:  :..|.:::|:||||||::|||..|.||:...|
  Rat   198 FGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262

  Fly   402 DFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDV 466
            .|:.|.:|::...|.||..:   ||..|.||..:||.||.::||.||||:..||..::|:...||
  Rat   263 PFQQLKQVVEEPSPQLPADK---FSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHEAKAADV 324

  Fly   467 PNWFQSI 473
            .::.:.|
  Rat   325 ASFVKLI 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	138/298 (46%)
Map2k6	NP_446155.1	PKc_MKK3_6	51..333	CDD:173729	137/284 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920