DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hep and abl1

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	XP_002936228.2	Gene:	abl1 / 100490771	XenbaseID:	XB-GENE-6054675	Length:	1128	Species:	Xenopus tropicalis

Alignment Length:	965	Identity:	211/965 - (21%)
Similarity:	365/965 - (37%)	Gaps:	211/965 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRR-TGNAEENKRILMDLDVVLKSHDCKY 255
            |||. :||  .||.|..|.|.:.:....|..:|||.::. |...||    .:....|:|......
Frog   267 TDIT-MKH--KLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEE----FLKEAAVMKEVKHPN 324

  Fly   256 IVKCLGCFVRDPDVWICMELMSM--CFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIH 318
            :|:.||...|:|..:|..|.|:.  ..|.|...:::.|...:|..:.....:|:.|| :|...||
Frog   325 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVTAVVLLHMATQISSAMEYL-EKKNFIH 388

  Fly   319 RDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGC---AAYMAPERIDPKKPKYDIRADVW 380
            ||:...|.|:.|...:|:.|||:| ||:.....|..||.   ..:.|||.:  ...|:.|::|||
Frog   389 RDLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESL--AYNKFSIKSDVW 450

  Fly   381 SLGITLVELAT-ARSPYEGCNTD--FEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQ 442
            :.|:.|.|:|| ..|||.|.:..  :|:|.|....|.|     ||  ..::..:.:.:|...:..
Frog   451 AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP-----EG--CPEKVYELMRECWQWSPL 508

  Fly   443 DRPKYPELLAQPFIRIYESA---------------KVDVPNWFQSIKDNRLRANGDPTLQRATAT 492
            |||.:.| :.|.|..:::.:               ||.|.|..|:           |.|...|..
Frog   509 DRPSFAE-IHQDFETMFQESSISDEVEKELGKKGLKVTVSNLLQA-----------PELPTKTRI 561

  Fly   493 GSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKT------IKPTQ---IPSYQQQQS 548
            ...:.......|.:.|..|.|.:......  :..||..|:|.      :.|..   :|  :.:::
Frog   562 TRRVPESKDENAETASVRAAGELDVFEPE--SAVSPLLPRKERGAGDGVLPDDDRLLP--KDKKT 622

  Fly   549 QFFMQSATQLPQTTTTTPTATTNCFGG-SGNGNGRG-NGSGGSGNGSG------SSSSASPLSPP 605
            ..|..:..:..:....||...::.|.. .|:...|. :|.|...||..      .|::.:.||..
Frog   623 NLFFSTLIKRKKKNAPTPPKRSSSFRDMEGHSERRSTDGEGKEANGGDLLDTFKLSTNGTALSNG 687

  Fly   606 S--AGIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFSSIGQSILRNLTTS--PFSQ 666
            |  ...|.|:..::||..|..:             ..||.:|....|..:..||:.:.|  |...
Frog   688 SIQGSTGFLSSQWKKSSTMTGR-------------QASPSEEETICSTSKRFLRSCSASCMPHGA 739

  Fly   667 KKHNSTATTIP--LPHNNQTLITDAATAAAAAATATTP--------PNIAATVLTTTPTTTPTWR 721
            |.....:.|:|  :..:...|.|..:.:...|.....|        |.      .|..|.||..|
Frog   740 KDTEWKSVTLPREITSSRCLLDTPGSDSLKKAEKPALPRKRGNESKPE------GTRGTVTPPPR 798

  Fly   722 LPTE----NSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQ--FPTESPTLQLTSQQQQQPQRL 780
            ||.:    |.:.:...|.|.|::..:|       :|.|.|::  .|..:|.      |:::...:
Frog   799 LPKKCEDPNDEVFKDADPSPNSSPPSL-------TPKLLRRKPAGPAGAPL------QKEEASNI 850

  Fly   781 QPG----NQSPIVLQRFYHQQNQ----LREKEAAE-------RYQQQRQQPPVGVTS--TNPFHS 828
            :.|    :..|...|..:..:::    ||..:.:|       :..:.:..||:.::|  ::|..|
Frog   851 RLGSVNSDTGPSTKQTSFAGKSEAELRLRRPKTSEPATKDKVKVLKVKPSPPLPLSSIGSSPSAS 915

  Fly   829 NYV----PPPPSTHSTSSQSSTQSTCSQI-------------AINPASISPSSGSGTGNMAGLGI 876
            :.:    .||..:|.||.........||.             :..|..:|.|....||.::|
Frog   916 SNLGKAAKPPSQSHDTSPSEPKHKLTSQTDELSKTPPPVPDSSKKPVLLSSSKPQVTGKLSG--- 977

  Fly   877 GSAPASGLGAAGHFGAGGTGEQLQYQP-LPIAAEATGTSPTLQSR--------SPEQQSDYGGNG 932
                  |:.|.|.          |.|| .|.::.:|...|.:.:|        .||:.|......
Frog   978 ------GMVAGGD----------QSQPSAPSSSSSTAFVPLISTRVSLRKTRQPPEKHSSPVTKE 1026

  Fly   933 NMVASKLSKLYARRQLLGQSSSSGASNSSLDGCSREQHDAGWFNTLAGAMKRQFATYVKTQLNST 997
            .::||    ....:..:.::|...||:|::...::..|          |....:...::...|..
Frog  1027 TVMAS----TECLKAAIARNSEQMASHSTVLEAAKNLH----------AFCTSYVDSIQQMRNKF 1077

  Fly   998 ATSPVASSMD---RDQEPVHPQPPAYRSVVNNGSGGKSYYYRTLSAASSSSNTSQ 1049
            |.....|.::   ||.: :.|.|.|    ...|:.....:.:.|::....|:..|
Frog  1078 AFREAISKLENSLRDLQ-ICPAPAA----AGGGAATSQDFSKLLTSVKEISDVVQ 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	88/307 (29%)
abl1	XP_002936228.2	SH3_Abl	92..145	CDD:212784
		SH2_ABL	150..243	CDD:198189
		PTKc_Abl	262..524	CDD:270645	83/275 (30%)
		F_actin_bind	1003..1128	CDD:385063	24/144 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000