DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hep and stk39

DIOPT Version :9

Sequence 1:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	XP_017953089.2	Gene:	stk39 / 100488948	XenbaseID:	XB-GENE-1012528	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	114/465 - (24%)
Similarity:	179/465 - (38%)	Gaps:	114/465 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SARVPPLATSASAATSATHAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASAS--------SS 102
            :|..|||.|.     ..||                .:.|.||.| ..|...|.|.        |:
Frog    29 TAEAPPLCTH-----RLTH----------------RRLPPPPSP-LRPGCQAVAEQRVNEPGRSA 71

  Fly   103 SSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPTPPHPPVS 167
            ....|:.:|..|...:..      ||.:|.:.......|..|   |:..:|   |...|...|:.
Frog    72 RRVRSSHSSNKPRRRSIS------TTSLSMSAEPQQQQSDSP---LHSPQP---PAAQPIGWPIC 124

  Fly   168 ETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTG 232
            ....:|:.:                          :|:|.:..|...:.......:|:|::
Frog   125 RDSYELQEV--------------------------IGSGATAVVQAALCKPRQERVAIKRI---- 159

  Fly   233 NAEENKRILMDLDVVLKS----HDCKY--IVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPV 291
            |.|   :....:|.:||.    ..|.:  ||.....||...::|:.|:|:|  ...:|.:.|..|
Frog   160 NLE---KCQTSMDELLKEIQAMSQCSHPNIVTYYTSFVVKEELWLVMKLLS--GGSMLDIIKHVV 219

  Fly   292 ----------PEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGIS---- 342
                      .|.|:..:....:..|.|| .::|.||||:|..|||:.|.|::::.|||:|
Frog   220 GRGEHKNGVLEESIIATILKEVLEGLDYL-HRNGQIHRDLKAGNILLGEDGSVQIADFGVSSFLA 283

  Fly   343 --GRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEV 405
              |.:..:|......|...:||||.::..: .||.:||:||.|||.:||||..:||.. ....:|
Frog   284 TGGDVTRNKVRKTFVGTPCWMAPEVMEQVR-GYDFKADMWSFGITAIELATGAAPYHK-YPPMKV 346

  Fly   406 LTKVLDSEPPCLPYGEG-----YNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIR-------I 458
            |...|.::||.|..|..     ..:.:.||..:..||.|:...||...|||...|.:       :
Frog   347 LMLTLQNDPPTLETGVEDKEMMRKYGKSFRKLISLCLQKDPSKRPTAAELLKCKFFQKSKNREYL 411

  Fly   459 YESAKVDVPN 468
            .|...:..||
Frog   412 IEKLLIKTPN 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	85/322 (26%)
stk39	XP_017953089.2	STKc_OSR1_SPAK	126..402	CDD:270787	82/313 (26%)
stk39	XP_017953089.2	OSR1_C	516..573	CDD:403428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920