DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rad and rap1gap2a

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_021337099.1	Gene:	rap1gap2a / 561339	ZFINID:	ZDB-GENE-061013-179	Length:	843	Species:	Danio rerio

Alignment Length:	574	Identity:	179/574 - (31%)
Similarity:	264/574 - (45%)	Gaps:	139/574 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 DSSTQTEPSPLYDNNHYHEECLRCNS-----------CGLNLTGPNQKRARRFKNQILCDLHFAD 625
            ||.:.:||              :.||           .||......||...|.|.:....|..:.
Zfish    34 DSMSDSEP--------------KVNSKKAGIRAAVILIGLLHKSRRQKEREREKERKQELLTISS 84

  Fly   626 VALMECS-----------------DFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFC 673
            |.|.||.                 |.:::::..|.:.      .:|.....|    |....::..
Zfish    85 VPLGECPPSPPRTAPPTMKSAEFFDMLERMQIPKTEE------TKKYKDDYI----PYPRIEDVL 139

  Fly   674 EE---YPHNLMPT-PGYWIECSRQKITMPTPHTIWDESDS-----EHEDIR----AGSASDAYLE 725
            |:   ||..::|. .|||||.....:..||      .|||     |::|:.    .|.....| .
Zfish   140 EKGGPYPQVILPQFGGYWIEDPEAPVGTPT------SSDSSFCEEENDDLSPSGGGGGGGFGY-R 197

  Fly   726 RECSDLYEDDEDSEATPSPRKKTTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLG 790
            .||:.                                   ....|.|:|.|.||.||:.:...:|
Zfish   198 MECNS-----------------------------------TSRAYRKHFLGKEHMNYYCTASSMG 227

  Fly   791 PVILSIKQETLNGRDQFRILVRAGSYTVH------GLIPASCVFADRYNREEVVRSLGKEV---N 846
            .:|:|:|.|..:|::..||::|:.:.|:|      |||....:       .::.:.|..:|   .
Zfish   228 HLIMSLKYEDADGQESLRIMLRSKTKTLHERIPLEGLIHLPSI-------PQIAKLLCDDVTGLK 285

  Fly   847 LNPPLTLGQLPDTPEELLKLDQVFIKSELKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGD 911
            .||.|    .|...:.::..|:..:.:..|.|||:.|..|.:||::..|||.:|.|.|||::|||
Zfish   286 FNPVL----YPRASQLIVSFDEHEVNNTFKFGVIYQKFGQTSEEELFGNNEETPAFAEFLSVLGD 346

  Fly   912 RVRLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVC 976
            .:.|:.|..::||||..|..||..||||.:|..||||||||.||:.:.|.|:||||||||||||.
Zfish   347 NIELQDFKGFRGGLDVSHGQTGSESVYTTFRQREIMFHVSTKLPFTEGDIQQLQRKRHIGNDIVA 411

  Fly   977 VVFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKP----TRYEVSVVTRDEVGAYKPYLWEQS 1037
            .:|.| :.|.|.|..|.|:|||.:|||:.     ..|    |.|:|||..|::|..:.|.|...|
Zfish   412 AIFQE-EPTPFVPDMIASNFLHAYILVQA-----ENPCTDHTTYKVSVTAREDVPPFGPPLPNPS 470

  Fly  1038 VFEKGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDLVMNLSNHAET 1091
            ||:|||.|||:.|||::|.|.|.|.:.|||:::||||:.:|::|...|  |.:|
Zfish   471 VFKKGPEFREYFLTKLINAENACYKSDKFAKLEERTRAALLDNLHDEL--HRQT 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	9/50 (18%)
		Rap_GAP	893..1074	CDD:280332	93/184 (51%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
rap1gap2a	XP_021337099.1	Rap_GAP	328..507	CDD:307998	93/184 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920