DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad and sipa1l3

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_005173729.1	Gene:	sipa1l3 / 561005	ZFINID:	ZDB-GENE-050420-109	Length:	1718	Species:	Danio rerio

Alignment Length:	913	Identity:	256/913 - (28%)
Similarity:	356/913 - (38%)	Gaps:	218/913 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 RDSNVAGRVTT---PPPPGKYQMTKKRDSLAAP-----------------EFPNFRQEQRPSTSS 294
            ||:.|.....:   |||..:..:.....|:..|                 |:|..|...|.|...
Zfish     3 RDTGVCATPISQPIPPPHLRLPLHNGHSSMGDPAPPRISVPKMGVRARIAEWPPRRALSRESLLE 67

  Fly   295 AGSCSDHSMPLIS----THSSTHHLAHQQ------VDSACQALP--PPTIITSSVTP--PATSPT 345
            .|..| |...|.|    ||.....|..|.      |:|..|..|  ||...|||..|  ..:|..
Zfish    68 NGQDS-HPDDLNSDDGLTHGGVTRLPPQVTRDADFVESGLQRTPDTPPRFRTSSFAPLRQRSSSE 131

  Fly   346 APKGRRDSQTQCGRVNRR-DSKAGVSPERAP-----------RLQRLQRQATAFDE-GCLPGGSR 397
            .....:|......|:.|. .|.:.::.:...           :.:|..:::||.|: ..|.|.|.
Zfish   132 ITLSEQDETEVDSRLFREYGSTSSINVQAVSEQSFFDMLSQFQQERPDQRSTAPDKLEELLGASI 196

  Fly   398 RG-------SQPALSPDPPDDCERRTS--RRDSLSPDSASRGGRRDSRTHLSPDRSHERDGSPRR 453
            .|       |.|.|. |.|:...|:.|  ...||...|..|..|..||......|....|..| .
Zfish   197 EGNHSHNFLSTPRLD-DRPESRVRKKSGGTESSLGTSSLFRKLRSSSRGETETPRGDMDDARP-P 259

  Fly   454 HTLRRQSSSAARSPRSPDSNSCCSSRDPSPCSRPQTQTTVEQNQRPAIRRQSTTEEILIARGFRR 518
            .||..:.....||....|:.|.......:...|..           |.:|::|......|.....
Zfish   260 ETLSSKPWLCVRSFAHYDAQSILFDLHEAAARRSY-----------AAQRRNTATGASAASSAGV 313

  Fly   519 QSTTEEMIRCRNFRRQSSQSDDVCRYRGRRDSSAQIIDG-TIGTMTVETTSTFFDSSTQTEPSPL 582
            .......|.........|.:||:        |...:::| |.|...:|.     .||....|
Zfish   314 SLAVSRAIALGGVEPSFSSTDDL--------SVKDLLEGSTPGLELLEQ-----GSSASLNP--- 362

  Fly   583 YDNNHYHEECLRCNSCGLNLTGPNQKRARRFKNQILCDLHFADVALMECSDFMQQLRSFKPQSLG 647
               |..|:..|.|... ||.||...:|...|                        |.|:..:...
Zfish   363 ---NSQHQLLLSCPHF-LNETGSYGERNVSF------------------------LSSWAERGEA 399

  Fly   648 CAVARRKSSTTLIFPLPPQACSDEFCEEYPHNLMPTPGYWIECSRQKITMPTPHTIWDESDSEHE 712
            |||..|                          |.|      .||...:::
Zfish   400 CAVEAR--------------------------LRP------RCSNASVSI--------------- 417

  Fly   713 DIRAGSASDAYLERECSDLYEDDEDSEATPSPRKKTTIEEQWDQQGAFELISVEQETYEKYFYGT 777
                            .|:..:|::|.          :|..  ||...|.:.:....|.::|||.
Zfish   418 ----------------LDVSPEDQNSR----------LERL--QQHCIEHVDLGARNYHEHFYGK 454

  Fly   778 EHWNYFTSDEDLGPVILSIKQETLNG----RD--QFRILVRAGS-YTVHGLIPASCVFADRYNRE 835
            ||||||.:||.||||.|||::|.|:.    :|  |:||:.|... .|:.|.|....|.:..  :.
Zfish   455 EHWNYFGTDEKLGPVALSIRREKLDDTKDLKDQYQYRIIFRTSEMVTMRGAILEDAVLSTA--KH 517

  Fly   836 EVVRSLG-KEV--NLNPPLTLGQL------PDTPEELLKLDQVFIKSELKVGVIFVKEDQYTEEQ 891
            ..||.|. |||  .:.|.|::..|      |...|:|||||:..:..:.|||::..:..|.|||:
Zfish   518 GTVRGLPLKEVLEYVLPELSISCLRLALSTPKVTEQLLKLDEQGLSQKHKVGILLCRAGQSTEEE 582

  Fly   892 ILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPY 956
            :.:|.|.:|.|..||.|||:.|.||||:||...|||..|.||..|:||.:::.||||||||:|||
Zfish   583 MYNNEEATPSFTAFLELLGETVCLRGFNKYAAQLDTKTDSTGTHSLYTTYQDYEIMFHVSTMLPY 647

  Fly   957 EKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKP----TRYE 1017
            ..::||:|.||||||||||.::|.|.....|:|..|:|||.|.|::|||     |.|    |.|.
Zfish   648 MPNNPQQLLRKRHIGNDIVTIIFQEPGALPFTPQNIRSHFQHVFVIVRV-----HNPCSDNTCYS 707

  Fly  1018 VSVVTRDEVGAYKPYLWEQSVFEKGP-MFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDL 1081
            |:|....:|..:.|.|....:..:.| .||.:||.||:|.|.|::.:.||..|..|||...|.||
Zfish   708 VAVTRMKDVPPFGPPLPSNGMMFRDPAAFRSFLLAKIINAENAAHKSEKFHTMATRTRQGYLRDL 772

  Fly  1082 VMN 1084
            ..|
Zfish   773 AEN 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	10/39 (26%)
		Rap_GAP	893..1074	CDD:280332	85/185 (46%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
sipa1l3	XP_005173729.1	Rap_GAP	584..765	CDD:307998	85/185 (46%)
		PDZ_signaling	912..982	CDD:238492
		Herpes_UL32	<1051..1470	CDD:283680
		SPAR_C	1432..1662	CDD:314711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910