DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rad and sipa1l2

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_009304425.1	Gene:	sipa1l2 / 497350	ZFINID:	ZDB-GENE-050208-66	Length:	1689	Species:	Danio rerio

Alignment Length:	844	Identity:	230/844 - (27%)
Similarity:	370/844 - (43%)	Gaps:	167/844 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 ITSSVTPPAT----SPTAPK-GRRDSQTQCGRVNR-RDSKAGVSPERAPRLQRLQRQATAFDEGC 391
            :..::.||..    :|..|| |.|      .||:. ...|.|:.|  .||.:.|.   |:|..|
Zfish    14 LNGNMGPPGANAQGTPAVPKMGVR------ARVSEWPQKKDGICP--PPRYESLM---TSFQNG- 66

  Fly   392 LPGGSRRGSQPALSPDPPDDCERRTSRRDSLSPDSAS---------RGGRRDSRTHLSPDRSHER 447
                     ||..||:            |::.|...|         :.|..:...| ||.:.|
Zfish    67 ---------QPIQSPE------------DAVKPSPGSPPNPSFLEAKYGLGELLNH-SPGKVH-- 107

  Fly   448 DGSPRRHTLRRQSSSAARSPRSPDSNSCCSSRDPSPCS-RPQTQTTV--EQNQRPAIRRQSTTEE 509
                  |.|:::|:|..       :.|...:.|....: .|.|..|:  |.....:|.||...:|
Zfish   108 ------HALQKRSNSDV-------TISDIGAEDMDQTAINPNTGATLHREYGSTSSINRQGLPDE 159

  Fly   510 ILIA--RGFRRQSTTEEMI----RCRNFRR-QSSQSDDVCRYRGRRDSSAQIIDGTIGTMTVETT 567
            ....  :||:.:.:.:...    ....||| :::.|..:       .::|||..|.|  :.:...
Zfish   160 AFFGNLKGFQSEHSEQPSAPPPHGFPEFRRYETTVSPSL-------QTAAQIARGDI--LCIPNY 215

  Fly   568 STFFDSSTQTEPSPLYDNNHYHEECLRCNSCGLNLTG-----PNQKRARRFKNQI-LCDLHFADV 626
            |.:.|||       |:.:....:..|:........|.     ...|..:|..::: .|..|...:
Zfish   216 SDYVDSS-------LFYSREREKSFLQRQKSEKGETSIFRRLKTMKSEQRQLSELDDCSRHGRPL 273

  Fly   627 ALMEC---SDFMQQLRSFKPQSLGCA-VARRKSSTT-------------LIFPLPPQACSD--EF 672
            :...|   .|....|.:........| :||||:.||             |..|.|...|..  :.
Zfish   274 SFQRCFSHYDVQSVLFNISEAVTNRANLARRKNITTGASAASQHQISGALDGPDPLPLCESPLDN 338

  Fly   673 CEEYPHNLMPTP--------GYWIEC----------SRQKITMPTPHTIWDESDSEHEDIRAGSA 719
            |||........|        |..:.|          ..:|:....|:     |...:.::...::
Zfish   339 CEELGQKACTDPDEGDGKSSGLVLSCPYFRNEIGGEGERKLNATKPN-----SAPPNSNVGDNNS 398

  Fly   720 SDAYLERECSD----LYEDDEDSEATPSPRKKTTIEEQWDQQGAFELISVEQETYEKYFYGTEHW 780
            .::.|...|::    :.|...::.|:   |:...|.....::...|.|.:....|.|:|:..||.
Zfish   399 IESTLSSHCTNAGVSVLEMSRENYAS---RENYAIPRDCIKRYIIEHIDMGAYYYHKFFFNKEHQ 460

  Fly   781 NYFTSDEDLGPVILSIKQETL-NGRD----QFRILVRAGSYT------VHGLIPASCVFADRYN- 833
            |||..||:||||.:||::|.| .|::    .:|::.|.|..|      :...:|::........
Zfish   461 NYFGVDENLGPVAVSIRREKLEEGKEGPQYNYRVIFRTGELTTLRGSILEDAVPSTAKHGTSRGL 525

  Fly   834 -REEVVRSLGKEVNLNPPLTLGQLPDTPEELLKLDQVFIKSELKVGVIFVKEDQYTEEQILDNNE 897
             .:||:..:..|||:.........|..||:||||||..:..:.|||:::.:..|.|||::.:|..
Zfish   526 PLKEVLEYVVPEVNIQCLRMAISSPKVPEQLLKLDQQGLSYQHKVGILYCQAGQSTEEEMYNNES 590

  Fly   898 NSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKHDPQ 962
            .||..||||.|||.||||:||.||:..||...|.||..|:||.:::.|:||||||:|||..::.|
Zfish   591 GSPALDEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDFELMFHVSTMLPYTPNNRQ 655

  Fly   963 KLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKPTR----YEVSVVTR 1023
            :|.||||||||||.::|.|..:..|:|..|:|||.|.||:|:|     |.|..    |.::|...
Zfish   656 QLLRKRHIGNDIVTIIFQEPGSLPFTPQNIRSHFQHVFIIVKV-----HNPCTEHVCYSIAVTRS 715

  Fly  1024 DEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDLVMNLSN 1087
            .:|.|:.|.:.:..:|.|..:||::||.|::|.|.:::.:.||..|..|||.:.|:|||.|.::
Zfish   716 KDVPAFGPLIPKGVMFPKSAVFRDFLLAKVINAENSAHKSEKFRAMATRTRQEYLKDLVENFTS 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	5/45 (11%)
		Rap_GAP	893..1074	CDD:280332	81/184 (44%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
sipa1l2	XP_009304425.1	Rap_GAP	586..766	CDD:280332	81/184 (44%)
		PDZ_signaling	914..987	CDD:238492
		SPAR_C	1432..1633	CDD:288714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910