DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad and CG5521

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster

Alignment Length:	1459	Identity:	236/1459 - (16%)
Similarity:	397/1459 - (27%)	Gaps:	607/1459 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SLAQLTDILREWSGGTKQQQQHHSQQQ------QQQLQQASRSKAQLNRRETLADLARSLPWRTS 156
            ||....:::.||:...:...:..|:..      ...|.:.:.|:|:..||  :..:     |:.|
  Fly   590 SLTHREELIIEWNKTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRR--IGSV-----WQGS 647

  Fly   157 TTTDASTGAGGSGGGGCTTYMAPRKRRESSADSGIRSMRSRRDSNTAEFVRHWNRRESGAVEEQP 221
            .:..|:     :||...:..::..::|||.|:|.  |.||                      |:.
  Fly   648 GSNSAA-----NGGSAASAAISQNRQRESLAESS--SSRS----------------------EET 683

  Fly   222 SVSVPVVVECSKSASRRGSGESYLSSSRRDSNVAGRVTTPPPPGKYQMTKKRDSLAAPEFPNFRQ 286
            |..||:                                                      ||..:
  Fly   684 SSQVPL------------------------------------------------------PNHPR 694

  Fly   287 EQRPSTSSAGSCSDHSMPLISTHSSTHHLAHQQVDSACQALPPPTIITSSVTPPATSPTAPKGRR 351
            .....|.|.|.....:.|:..|...:...:...:.||.:        :|.:.....:...||..:
  Fly   695 PHHQHTQSQGGTGHGTRPIPLTPMLSRSYSEGSLASAAR--------SSRIRRRRAATPKPKALQ 751

  Fly   352 DSQTQCGRVNRRDSKAGVSPERAPRLQRLQRQATAFDEGCLPGGSRRGSQPALSPDPPDDCERRT 416
            .||....|:|.:|.:      ||..|..|.|:..|.:......|.......:.||.|
  Fly   752 PSQLAENRINPQDLR------RAMSLDSLARKGDAEETDSYQEGDNESGAGSRSPSP-------- 802

  Fly   417 SRRDSLSPDSASRGGR-RDSRTHLSPDRSHERDGSPRRHTLRRQSSSAARSPR------------ 468
                  :..|...||. :|::..:.........||     ....|:|.:.|.|
  Fly   803 ------TASSGIEGGSIKDAQLQIDASLDDANSGS-----YGSGSNSGSISGRRCIILGGSAEGW 856

  Fly   469 SPDSNSCC----------SSRDPSPCSRPQ--------TQT--TVEQNQRPAIRRQSTTE----- 508
            .|||.|..          .:|.|......|        ||.  .::|||..:...|:|..
  Fly   857 HPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPPLV 921

  Fly   509 ------------EILIARGFRRQSTTEEMIRCR-------NFRR---------QSSQSDD----- 540
                        .:.:.|.|::.......:.|.       |.::         |....:|
  Fly   922 PPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQGAVNMQQLPLFYHALHQLLTGEDRDLIY 986

  Fly   541 --------------------------------------VCRYRGRRDSSAQIIDGTIGTMTVETT 567
                                                  |.|...|.:.:|     .:|::....:
  Fly   987 AILKHLEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAA-----LLGSLLCYPS 1046

  Fly   568 STFFDSSTQTEP--------SPLYDNNHYHEECLRC--------------NSCG----LNLTGP- 605
            |....|..|..|        |.|.|  |.....|||              :..|    :.|:.|
  Fly  1047 SLLTRSVLQPTPQKFELMECSDLQD--HILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPL 1109

  Fly   606 ---NQKRARRFKNQILCDLHFADV------------------------------------ALMEC 631
               |..||..|:..:   .|..||                                    :|..|
  Fly  1110 PASNSGRANLFQQAV---PHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAVDSLKLC 1171

  Fly   632 SDFMQQLRSFK--PQSLGCAVAR----------RKSSTTLIFPLPPQACSDEFCEEYPHNLMPTP 684
            ::..:||.:.:  ||.:..|:.:          :.|...::..|  ..|..|||...|..:|.||
  Fly  1172 AERGRQLAAIERVPQLIITAICKALEIQSVTKPKDSDKVVLTSL--MLCLGEFCMAIPAPIMLTP 1234

  Fly   685 ----GYWIECSRQKITMPTPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEAT---- 741
                |..:.....::.:...     .....||.::..:..|..:.....||..|....|||
  Fly  1235 FNEQGDTLVLQVLRVLLQVA-----SGAPRHERVKLTADDDFDMHIAHDDLQGDGRLPEATYQTS 1294

  Fly   742 --------------------------------PSPRKKTTIEEQWD------------QQGAFEL 762
                                            .:.|..:.:|||.|            ::.:.||
  Fly  1295 ETIQKCITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSVEL 1359

  Fly   763 ISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNG----------RDQFRILVRAGSYT 817
            .||         ...::...|..:..|....:.:....|.|          ..|.|:|:|    .
  Fly  1360 PSV---------VSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMR----D 1411

  Fly   818 VHGLI--PASCVFADRYNREEVVRSLGKEVNLNP---------------------------PLTL 853
            ::|..  .||.::::..|.||..::..|..:..|                           ||..
  Fly  1412 LNGKACWDASILYSEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAK 1476

  Fly   854 GQLPD--------------TPE------------------------------------------- 861
            ...||              :||
  Fly  1477 DMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASPLSGNQEAQAISVILNQRLLEQEFVTHS 1541

  Fly   862 ----------------------------------------------------------------- 861

  Fly  1542 TQAPSPALRHASSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTH 1606

  Fly   862 ----------ELLKLDQVFIKSELKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVRLR 916
                      ||..:|....:...|:.||:|...|..:..||.|...|..::.|::.||..:.|.
  Fly  1607 LLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLE 1671

  Fly   917 GFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVFLE 981
            ..:.:.|||.  ....|..:.|.....:|:::||:|.:|.:..:.. |.:.||:|||.|.:|:.|
  Fly  1672 THNGFLGGLP--RQGCGATAPYYATPFLEVVYHVATRMPSDSSEAM-LLKTRHLGNDEVHIVWSE 1733

  Fly   982 ADNTRFSPACIKSHFLHTFILVRVSARIKHKPTR---YEVSVVTRDEVGAYKPYLWEQSVFEKGP 1043
             .|..:....:.:.|....|:|        .|.|   :.|:|..:.||..:.|...|..|  .|.
  Fly  1734 -HNRDYRRDILPTEFCDVLIVV--------YPLRNGLFRVTVNRKPEVPWFGPLANESVV--SGA 1787

  Fly  1044 MFREWLLTKIVNGERASYSA-PKFARM-QERTR-----------SQMLEDLVMNLSNHAETGQIP 1095
            .....:....:|..|...:| |.:.:. :||.|           |...||....:.|       |
  Fly  1788 CLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYN-------P 1845

  Fly  1096 KPYRR-GSWRPIGEDEYIKMLHARVLDNN 1123
            .|... |:.|..........|.:.:||:|
  Fly  1846 MPLSTLGTLRESNASSSAAPLASALLDHN 1874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	12/61 (20%)
		Rap_GAP	893..1074	CDD:280332	46/185 (25%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	46/185 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910