DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad and Sipa1l2

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_038953828.1	Gene:	Sipa1l2 / 361442	RGDID:	1306269	Length:	1741	Species:	Rattus norvegicus

Alignment Length:	909	Identity:	236/909 - (25%)
Similarity:	353/909 - (38%)	Gaps:	272/909 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 RDSQTQCGRVNRRDSKAGVSPERAPR---------------LQRLQRQATAFDEGCLPGGSRRGS 400
            |.||.:..::.|..||. ..|.||.:               :.......::..||...||.....
  Rat     5 RPSQAEKHKLGRAASKF-KDPSRAMQSDDYFARKFKAINGSMGPATLNTSSLSEGGGGGGGPANG 68

  Fly   401 QPA---------LSPDPP-DDCERRTS------RRDSLSPDSAS---RGGRRDSRTHLSPDRSHE 446
            .||         :|..|| .||.:..:      .|...|.:||:   :.|:.|     ..||..|
  Rat    69 TPAVPKMGVRARVSEWPPKKDCSKDLACKTLWESRSQSSYESATSIIQNGQND-----QVDRQQE 128

  Fly   447 RD-----------------GSPRR--HTLRRQSSSAARSPRSPDSNSCCSSRD--PSPCSRPQTQ 490
            ..                 .||:|  |.:|::|:|..       :.|...:.|  ......|.|.
  Rat   129 EQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDI-------TISDIDTEDVLDQHAVNPNTG 186

  Fly   491 TTV--EQNQRPAIRRQSTTEEILIA--RGFRRQS------------------------------- 520
            ..:  |.....:|.||..:.|.:.|  ||:|.:|
  Rat   187 AALHREYGSTSSIDRQGLSGENVFAMLRGYRIESYDPKVTSSFGFPDFFPCDTAISPSLHAAAQI 251

  Fly   521 TTEEMIRCRNF------------------RRQSSQSDDVCRYRGRRDSSAQIIDGTIGTMTVETT 567
            :..|.:|....                  ||..|:|.:...:|..|              ||::.
  Rat   252 SRGEFVRISGLDYMDGGLLMGRDRDKPFKRRLKSESVETSLFRKLR--------------TVKSE 302

  Fly   568 STFFDSSTQTEPSPLYDNNHYHEECLRC------NSCGLNLTGPNQKRARRFKNQILCDLHFADV 626
            ...|..::..|...| |.......|.||      .|...|:   |:..|.|
  Rat   303 HETFKFTSDLEEGRL-DRGIRPWSCQRCFAHYDVQSILFNI---NEAMATR-------------- 349

  Fly   627 ALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEEYPHNLMPTPGYWIEC- 690
                                 .:|.:||:.||          ......:.|..:.|..|    |
  Rat   350 ---------------------ASVGKRKNITT----------GASAASQTPVPVGPAGG----CE 379

  Fly   691 ----SRQKI-TMPTPHTIWDESDSEHEDI----------------------RAGSASDAYLEREC 728
                |::.: :...|..  ||.|.:..|:                      ||.|||.:..| .|
  Rat   380 SPLGSKEDLNSKENPDA--DEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSASFSSGE-SC 441

  Fly   729 SDLYEDDEDSEATPS-------PRKKTTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSD 786
            |  :|....|..|.:       ||:...|..:..::...|.:.:....|.|:|||.||.|||..|
  Rat   442 S--FESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHVDLGAYYYRKFFYGKEHQNYFGID 504

  Fly   787 EDLGPVILSIKQETL-------NGRDQFRILVRAGSYT------VHGLIPASCVFADRYNREEVV 838
            |:||||.:||::|.:       ..:..:|:..|....|      :...:|::.       |....
  Rat   505 ENLGPVAVSIRREKVEDPREKEGSQFNYRVAFRTSELTTLRGAILEDAVPSTA-------RHGTA 562

  Fly   839 RSLG-KEV--NLNPPLTLGQL------PDTPEELLKLDQVFIKSELKVGVIFVKEDQYTEEQILD 894
            |.|. |||  .:.|.|::..|      |..||:|||||:..:..:.|:|:::.|..|.|||::.:
  Rat   563 RGLPLKEVLEYVIPELSIPCLRQAANSPKVPEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYN 627

  Fly   895 NNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKH 959
            |....|.|:|||.|||.||||:||.||:..||...|.||..|:||.:::.|:||||||||||..:
  Rat   628 NETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDFELMFHVSTLLPYMPN 692

  Fly   960 DPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKPTR----YEVSV 1020
            :.|:|.||||||||||.::|.|.....|:|..|:|||.|.|::|:|     |.|..    |.|.|
  Rat   693 NRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFVIVKV-----HNPCTENVCYSVGV 752

  Fly  1021 VTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDLVMN 1084
            ....:|..:.|.:.:...|.|..:||::||.|::|.|.|::.:.||..|..|||.:.|:||..|
  Rat   753 SRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	9/45 (20%)
		Rap_GAP	893..1074	CDD:280332	81/184 (44%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
Sipa1l2	XP_038953828.1	Rap_GAP	626..806	CDD:396632	81/184 (44%)
		PDZ_signaling	951..1021	CDD:238492
		SPAR_C	1423..1685	CDD:403176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910