Protein Alignment rsh and rsh

DIOPT Version :10

• Sequence 1: NP_001285176.1
• Gene: rsh / 32253
• FlyBaseID: FBgn0265597
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_061500025.1
• Gene: rsh / 3290563
• VectorBaseID: AGAMI1_011524
• Length: 1556
• Species: Anopheles gambiae
• Alignment Length: 1725
• Identity: 1219/1725 - (70%)
• Similarity: 1322/1725 - (76%)
• Gaps: 219/1725 - (12%)

  Fly     1 MSKLRHYRSMDQPCSSTCVVIRKKTMTAICFVCNLPIMSHQVGLVWQGGNGWDDLVREQLEESTI 65
            |:||||||                |||||||||||||||||||||||||||||||||||:|||||
Mosquito     1 MAKLRHYR----------------TMTAICFVCNLPIMSHQVGLVWQGGNGWDDLVREQVEESTI 49

  Fly    66 RQRLGGRRDSAAQIT--TPPSTSPPPGLQRRRRSSLAQLTDILREWSGGTKQQQQHHSQQQQQQL 128
            ||||||||||||||:  :|||||||||.|||||||||||||||||||||..::|
Mosquito    50 RQRLGGRRDSAAQISGASPPSTSPPPGAQRRRRSSLAQLTDILREWSGGGSKRQ----------- 103

  Fly   129 QQASRSKAQLNRRETLADLARSLPWRTSTTTDASTGAGGSGGGGCTTYMAP--RKRRESSADSGI 191
                  ||.||||||||||||||||..:||.::......||       .||  |||||||||||:
Mosquito   104 ------KAPLNRRETLADLARSLPWNKATTGESYNSQNNSG-------HAPPLRKRRESSADSGV 155

  Fly   192 RSMRSRRDSNTAEF--VRHWNR-----------RESGAVEEQPSVSVPVVVECSKSASRRGSGES 243
            :|...||||:.::|  .|.|.|           ||.....|:.........:..::.|||.|.:|
Mosquito   156 KSWSYRRDSHVSDFRKEREWEREREKERERERERERERERERDRDDYIYSTDNYRNGSRRNSNDS 220

  Fly   244 YLS-SSRRDSNVAGRVTTPPPPGKYQMT--KKRDSLAAPEFPNFRQEQRPSTSSAGSCSDHSMPL 305
            ... ||||||.:.|..|.||||.|...|  |::|||...|.|||||||||||||..|   .|.||
Mosquito   221 SRDRSSRRDSTIGGTATPPPPPPKVVGTQRKRKDSLVVAEMPNFRQEQRPSTSSTAS---DSGPL 282

  Fly   306 ISTHSSTHHLAHQQVDSACQALPPPTIITSSVTPPATSPTAPKGRRDSQTQCG-RVNRRDSKAGV 369
            ...      :||  |||||||||||||||||||||||||||.||||||.|||| ::.||||:  |
Mosquito   283 FVA------VAH--VDSACQALPPPTIITSSVTPPATSPTAQKGRRDSTTQCGTKMTRRDSR--V 337

  Fly   370 SPERAPRLQRLQRQATAFDEGCLP--GGSRRGSQPALSPDPPDDCERRTSRRDSLSPDSASRGGR 432
            |||||.||.:|||||||:||.|||  |.|||.||||||||  .:...|.:|||||||||||| ||
Mosquito   338 SPERAQRLSKLQRQATAYDESCLPPGGWSRRSSQPALSPD--GEGPERQARRDSLSPDSASR-GR 399

  Fly   433 RDSRTHLSPDRSHERDGSPRR-HTLRRQSSSAARSPRSPDSNSCCSSRDPSPCSRPQTQTTVEQN 496
            ||||:||||||||||:||||| ..||||||||||.||||||:|||||||.|||:||...|  |..
Mosquito   400 RDSRSHLSPDRSHEREGSPRRSRRLRRQSSSAARQPRSPDSSSCCSSRDASPCARPPPPT--EST 462

  Fly   497 QRPAIRRQSTTEEILIARGFRRQSTTEEMIRCRNFRRQSSQSDDVCRYRGRRDSSAQIIDGTIGT 561
            .||:||||||||||||||||||||||||||||||||||||||||..|||||||||||||||||||
Mosquito   463 ARPSIRRQSTTEEILIARGFRRQSTTEEMIRCRNFRRQSSQSDDTSRYRGRRDSSAQIIDGTIGT 527

  Fly   562 MTVETTSTF------FDSSTQTEPSPLYDNNHYHEECLRCNSCGLNLTGPNQKRARRFKNQILCD 620
            |||||||..      ...|.::||||||:||||||||||||||||||||||||||||||||||||
Mosquito   528 MTVETTSKLRRLHGSSQQSHESEPSPLYENNHYHEECLRCNSCGLNLTGPNQKRARRFKNQILCD 592

  Fly   621 LHFADVALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEEYPHNLMPTPG 685
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||:||||
Mosquito   593 LHFADVALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEDYPHNLIPTPG 657

  Fly   686 YWIECSRQKITMPTPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEATPSP----RK 746
            ||||||||||..|..|||||:|:||||:...|...:..|||.|||||||||||:..||.    ||
Mosquito   658 YWIECSRQKIAFPNQHTIWDDSESEHEEAARGITVEPQLERNCSDLYEDDEDSDNVPSSQRFRRK 722

  Fly   747 KTTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNGRDQFRILV 811
            ||.|||||:||..|||.|||||||||||||||||||||:|||||||||||||||:||||||||||
Mosquito   723 KTAIEEQWEQQQGFELTSVEQETYEKYFYGTEHWNYFTNDEDLGPVILSIKQETINGRDQFRILV 787

  Fly   812 RAGSYTVHGLIPASCVFADRYNREEVVRSLGKEVNLNPPLTLGQLPDTPEELLKLDQVFIKSELK 876
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   788 RAISYTVHGLIPASCVFADRYNREEVVRSLGKEVNLNPPLTLGQLPDTPEELLKLDQVFIKSELK 852

  Fly   877 VGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTNW 941
            ||||:|||.|||||||||||||||||:|||.||||:||||||||||||||||||||||:||||||
Mosquito   853 VGVIYVKEGQYTEEQILDNNENSPLFEEFLQLLGDKVRLRGFDKYKGGLDTVHDLTGLYSVYTNW 917

  Fly   942 RNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRVS 1006
            |:|||||||||.||||||||||||||||||||||||||||||||.||||||||||||||||||||
Mosquito   918 RSIEIMFHVSTQLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTAFSPACIKSHFLHTFILVRVS 982

  Fly  1007 ARIKHKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQE 1071
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   983 ARIKRKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQE 1047

  Fly  1072 RTRSQMLEDLVMNLSNHAETGQIPKPYRRGSWRPIGEDEYIKMLHARVLDNNTHHEQQQQLLLQQ 1136
            |||||||||:|.||:||||||||||||||||||||
Mosquito  1048 RTRSQMLEDIVANLANHAETGQIPKPYRRGSWRPI------------------------------ 1082

  Fly  1137 QHMQHTQHMQHLPSHNICCYCNNNATELHTAGAIHNNNDNNNTTTTTTFTHRHNNNNNNYSEQQQ 1201
                  ..:.|..||
Mosquito  1083 ------DILMHTDSH-------------------------------------------------- 1091

  Fly  1202 QQLPQQQQHDSQQQQQLLQPQQHQLLHQLQLSTSSLTHTSCCAMLHLCARHSHMRPSSPLLDSVR 1266
                                              .|:||....::..|.|  |||||||||||||
Mosquito  1092 ----------------------------------ILSHTDSGFLIRNCTR--HMRPSSPLLDSVR 1120

  Fly  1267 DQFEDYDQLAKDFTRVFLNEEPSCLTNAHLFDVVFLVGQSKQKARFIGVRAILGVRSRVFQEMLY 1331
            |||||||||||||||||||.|||||.||.|||||||||||||:||||||||||||||||||||||
Mosquito  1121 DQFEDYDQLAKDFTRVFLNSEPSCLQNAQLFDVVFLVGQSKQRARFIGVRAILGVRSRVFQEMLY 1185

  Fly  1332 GIQTGFGSPQIPVAEIFARPAPSLVSPQNQKPKSNNYLTVPDSDSIRPKSVPSSPMVKRAFSRLG 1396
            ||||||||||:||||:.|||||:|:|||||:|||:|:|.|||.:|.|||||||||||||||||||
Mosquito  1186 GIQTGFGSPQVPVAELLARPAPTLLSPQNQRPKSSNFLQVPDIESPRPKSVPSSPMVKRAFSRLG 1250

  Fly  1397 TITAGWGRSIRNKNTNQLNPDDKKKWISSTDCSNRDSKD-KDKDKPGNNQLAVPRLSVCADAQKV 1460
            |||||||||||.::| |||.:|||||.||.|||::|.|: ..|.|....||||||||||||||||
Mosquito  1251 TITAGWGRSIRKQHT-QLNAEDKKKWASSQDCSDKDGKETSSKSKANAGQLAVPRLSVCADAQKV 1314

  Fly  1461 DRAKLAQTEFNIIEFDPDTFRVLLDYLHTGTCPLTCVSIPGLLCAAEHYDLPELLQACFHHCKQF 1525
            ||||||||||.|||||||||||||||||||:|||||.|||||:||||||||||||||||||.|||
Mosquito  1315 DRAKLAQTEFTIIEFDPDTFRVLLDYLHTGSCPLTCTSIPGLICAAEHYDLPELLQACFHHAKQF 1379

  Fly  1526 LRIEVVCPMLISLENYYWRYTSASELVNMILSFVESKAHSLFKCPEFLHLSESMVQMIMCRELQT 1590
            |||:|||.||.:|||||||||||||||||||:|||::|::||:..:||.||||||||||||.|:.
Mosquito  1380 LRIDVVCTMLTALENYYWRYTSASELVNMILAFVETRAYALFQNADFLTLSESMVQMIMCRNLEI 1444

  Fly  1591 PEIRKFEAMLAWAQHKVGKLKNHPNKDTQFEFECIMERLTRDLNLCRISPSELLTVVLPSKSMKN 1655
            ||:|||||||||.::|| |.|.....|.:.||.||||||.|||.|.||||.||:.:|||||::||
Mosquito  1445 PEVRKFEAMLAWTKYKV-KSKASAKTDAKVEFRCIMERLARDLKLHRISPQELIKIVLPSKAIKN 1508

  Fly  1656 ERIMETLMVQVNLGTYRMPE--LDAYRQQLRQQES 1688
            |||:||||.|.|.|.||:.:  |:|.:|:|::|:|
Mosquito  1509 ERILETLMYQANSGMYRIQDSYLEACQQRLQKQDS 1543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rsh	NP_001285176.1	PHA03309	<207..539	CDD:165564	225/349 (64%)
		LIM	<583..623	CDD:259829	38/39 (97%)
		Rap_GAP	893..1074	CDD:460463	172/180 (96%)
		BTB_POZ	1289..>1344	CDD:453885	50/54 (93%)
		BTB	<1467..1526	CDD:197585	53/58 (91%)
		BACK	1531..1603	CDD:475122	54/71 (76%)
rsh	XP_061500025.1	None