Protein Alignment rsh and Rap1gap2

DIOPT Version :10

• Sequence 1: NP_001285176.1
• Gene: rsh / 32253
• FlyBaseID: FBgn0265597
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_017452778.1
• Gene: Rap1gap2 / 303298
• RGDID: 1304590
• Length: 808
• Species: Rattus norvegicus
• Alignment Length: 577
• Identity: 183/577 - (31%)
• Similarity: 280/577 - (48%)
• Gaps: 105/577 - (18%)

  Fly   629 MECSDFMQQLRSFKPQSLGCAVAR---RKSSTTLIFPLPPQACSDEFCEE---YPHNLMPT-PGY 686
            |:.::|.:.|.  |.|.:.....|   :|:....|    |....:|..|:   ||..::|. .||
  Rat   131 MKSAEFFEMLE--KMQGIKLEEQRPGPQKNKEDYI----PYPSIEEVVEKGGPYPQIILPQFGGY 189

  Fly   687 WIECSRQKITMPTPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEATPSPRKKTTIE 751
            ||| ..:.:..||               ..||:           :||::|:...:|:     |..
  Rat   190 WIE-DPENVGTPT---------------SLGSS-----------VYEEEEEDSLSPN-----TFG 222

  Fly   752 EQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNGRDQFRILVRAGSY 816
            .:.:.:|       |...|.::|.|.:|.|::.:...||.:|||||.|...|.:..||::|:...
  Rat   223 YKLECRG-------EARAYRRHFLGKDHLNFYCTGSSLGNLILSIKCEEAEGIEYLRIILRSKLK 280

  Fly   817 TVHGLIPASCVFADRYNREEVVRSLGKE-------VNLNPPLTLGQLPDTPEELLKLDQVFIKSE 874
            |||..||.:.:     ::...|..:.|.       :..||.|    .|...:.::..|:..:.:.
  Rat   281 TVHERIPLAGL-----SKLPSVPQIAKAFCDDAVGLKFNPVL----YPKASQMIVSYDEHDVNNT 336

  Fly   875 LKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYT 939
            .|.|||:.|..|..||::..|||.||.|.|||.||||.:.|:.|..::||||..|..||:.||||
  Rat   337 FKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYT 401

  Fly   940 NWRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVR 1004
            .:|:.||||||||.||:...|.|:||||||||||||.::|.| :||.|.|..|.|:|||.:|:|:
  Rat   402 TFRDREIMFHVSTKLPFTDGDTQQLQRKRHIGNDIVAIIFQE-ENTPFVPDMIASNFLHAYIVVQ 465

  Fly  1005 VSARIKHKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARM 1069
            ..:.....|: |:|||..|::|.|:.|.|....||:||..|||:||||:.|.|.|...:.|||::
  Rat   466 AESTGTETPS-YKVSVTAREDVPAFGPPLPSPPVFQKGTEFREFLLTKLTNAENACCKSDKFAKL 529

  Fly  1070 QERTRSQMLEDLVMNLSNHAET--GQIPKPYRRGSWRPIGEDEYIKMLHARVLDNNTHH---EQQ 1129
            ::|||:.:|::|...|..|.:.  |..|:           ||::         :|..|.   |..
  Rat   530 EDRTRAALLDNLHDELHTHTQVMLGMGPE-----------EDKF---------ENGGHGGFLESF 574

  Fly  1130 QQLLLQQQHMQHTQHMQHLPSHNICCYCNNNATELHTAGAIHNNNDNNNTTTTTTFT 1186
            ::.:..:.|...|........|      ..|.....:.|.:||:.:    .|.|||:
  Rat   575 KRAIRVRSHSMETMVGSQRKLH------GGNIPGSLSGGIVHNSME----VTKTTFS 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rsh	NP_001285176.1	PHA03309	<207..539	CDD:165564
		LIM	<583..623	CDD:259829
		Rap_GAP	893..1074	CDD:460463	92/180 (51%)
		BTB_POZ	1289..>1344	CDD:453885
		BTB	<1467..1526	CDD:197585
		BACK	1531..1603	CDD:475122
Rap1gap2	XP_017452778.1	Rap_GAP	355..534	CDD:460463	92/180 (51%)