DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad and Sipa1l3

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001358027.1	Gene:	Sipa1l3 / 292771	RGDID:	1311432	Length:	1776	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	245/906 - (27%)
Similarity:	368/906 - (40%)	Gaps:	186/906 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 GESYLSSSRRDS---------NVAGRVTTPPPPGKYQMTKKRDSLAAPEFPNFRQEQRPSTSSAG 296
            |||..:::.|.|         .|..||...||        |||:|        |::..||.|..
  Rat    51 GESPATATTRPSPTTPAMPKMGVRARVADWPP--------KRDAL--------REQSNPSPSQD- 98

  Fly   297 SCSDHSMPLISTHSSTHHLAHQQVDSACQALPPPTIITSSVTPPATSPTAPKGRRDSQTQCGRVN 361
                      :....|..:||...:.....||..|        ||:|     |.|...    |::
  Rat    99 ----------TDGVKTTKVAHSMRNLQNGQLPSST--------PASS-----GSRAFH----RLS 136

  Fly   362 RRDSKAGVSPERAPRLQRLQRQATAFDEGCLPGGSRRGSQPALSP-DPPDDCERRTSRRDSLSPD 425
            ||.||.....:..||     ....||    ||...|..|:..||. |..:..:.|.:|...:.|.
  Rat   137 RRRSKDVEFQDGWPR-----SPGRAF----LPLRHRSSSEITLSECDVEEPGDPRGTRHPGVLPL 192

  Fly   426 SASRGGRRDSRTHLSPDRS------HERDGSPRRHTLRRQSSSAARSPRSPDSNSCCSSRDPSPC 484
            ....|..........|::|      ..|...|.....:..|......|.:....||.:..||.
  Rat   193 FREYGSTSSIDVQGVPEQSFFDILNEFRSEQPEARGSQNLSELLRVDPGALSGGSCGAKGDPR-- 255

  Fly   485 SRPQTQTTVE--QNQRPAIRRQSTTEEILIARGFRRQSTTEEMIRCRNFR--RQSSQSDDVCRYR 545
               ..|.|.:  |:.:|...::...::.:  ||.....|.:..|    ||  |.|....:|.|..
  Rat   256 ---NGQPTKDSLQSLQPLKEKEKARKKPV--RGLGSGDTVDSSI----FRKLRSSKPEGEVGRPL 311

  Fly   546 GRRDSSAQIIDGTIGTMTVETTSTFFDSSTQTEPSPLYDNNHYHEECLRCNSCGLNLTGPNQKRA 610
            |..:......:.: .....:.:...||..     |.|:|               ||....|:...
  Rat   312 GETEEGRSPPEAS-RPWVCQKSFAHFDVQ-----SMLFD---------------LNEAAANRVSV 355

  Fly   611 RRFKNQILCDLHFADVALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDE--FC 673
            .:.:|..      ...:....:..|..|.:.:..|||              .|.|...|.|  .|
  Rat   356 AQRRNTT------TGASAASAASAMVALTASRAHSLG--------------TLDPTFTSTEDLNC 400

  Fly   674 EEYPHNLMPTPGYWIECSRQKITMPTPH---TIWDESDSEHEDIRA-----GSASDAYLERECSD 730
            :|   ||....|   :.:...:.:..||   .|..|.:......||     |.:|:|::......
  Rat   401 KE---NLEQDLG---DDNSNDLLLSCPHFRNEIGGERERNVSFSRASVGSPGGSSEAHMAEPALS 459

  Fly   731 LYEDDEDSEATPSPRKKTTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILS 795
            .:..:........|:::...:.: .:|.:.|.:.:....|:.||.|.||.|||..||.||||.:|
  Rat   460 THRTNASISVLEVPKEQQRTQSR-PRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVS 523

  Fly   796 IKQETLNGRD------QFRILVRA-------GSY--------TVHGL---IPASCVFADRYNREE 836
            ||:|.|....      |:||:.|.       ||.        |.||.   :|.          ::
  Rat   524 IKREKLEDHKDHGPQYQYRIIFRTRELITLRGSILEDATPTATKHGTGRGLPL----------KD 578

  Fly   837 VVRSLGKEVNLNPPLTLGQLPDTPEELLKLDQVFIKSELKVGVIFVKEDQYTEEQILDNNENSPL 901
            .:..:..|:|::........|...|:|||||:..:..:.|||:::.|..|.:||::.:|.|..|.
  Rat   579 ALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPA 643

  Fly   902 FDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKHDPQKLQR 966
            |:|||.||||:|.|:||.||...||...|.||..|:||.:::.||||||||||||..::.|:|.|
  Rat   644 FEEFLDLLGDKVCLKGFTKYAAQLDVKTDSTGTHSLYTTYQDYEIMFHVSTLLPYTPNNRQQLLR 708

  Fly   967 KRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKPTR----YEVSVVTRDEVG 1027
            |||||||||.::|.|.....|:|..|:|||.|.||:|||     |.|..    |.::|....:..
  Rat   709 KRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRV-----HNPCTENVCYSMAVTRSKDAP 768

  Fly  1028 AYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDLVMN-LSN 1087
            .:.|.:...:.|.|..:||::||.|::|.|.|::.:.||..|..|||.:.|:||..| :||
  Rat   769 PFGPPIPNGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSN 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	5/39 (13%)
		Rap_GAP	893..1074	CDD:280332	82/184 (45%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
Sipa1l3	NP_001358027.1	Rap_GAP	635..815	CDD:396632	82/184 (45%)
		PDZ_signaling	960..1030	CDD:238492
		PHA03247	<1065..1706	CDD:223021
		SPAR_C	1471..1721	CDD:403176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910