DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad and Sipa1l2

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001074806.1	Gene:	Sipa1l2 / 244668	MGIID:	2676970	Length:	1722	Species:	Mus musculus

Alignment Length:	824	Identity:	226/824 - (27%)
Similarity:	343/824 - (41%)	Gaps:	209/824 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 PGGSRRGSQPALSPDPP-DDCER----RT---SRRDSL--SPDSASRGGRRDSRTHLSPDRSHER 447
            |...:.|.:..:|..|| .||.:    :|   ||..|.  |..|..:.|:.|.... .|:...:.
Mouse    70 PAVPKMGVRARVSEWPPKKDCSKDLACKTLWESRSQSSYESVTSIIQNGQNDQGDR-QPEEQLDL 133

  Fly   448 D-------------GSPRR--HTLRRQSSSAARSPRSPDSNSCCSSRD--PSPCSRPQTQTTV-- 493
            |             .||:|  |.:|::|:|..       :.|...:.|  ......|.|...:
Mouse   134 DFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDI-------TISDIDTEDVLDQHAVNPNTGAALHR 191

  Fly   494 EQNQRPAIRRQSTTEEILIA--RGFRRQSTTEEMIRCRNFRRQSSQSDDVCRYRGRRDSSAQIID 556
            |.....:|.||..:.|.:.|  ||:|.:|...:                              :.
Mouse   192 EYGSTSSIDRQGLSGENVFAMLRGYRIESYDPK------------------------------VT 226

  Fly   557 GTIGTMTVETTSTFFDSSTQTEPSPLYDNNHYHEECLRCNSCGLN------LTGPNQKR--ARRF 613
            |:.|      ...||...|...||..........|.:|.:  ||:      |.|.::.:  .||.
Mouse   227 GSFG------FPDFFPCDTAISPSLHAAAQISRGEFVRIS--GLDYMDGGLLMGRDRDKPFKRRL 283

  Fly   614 KNQILCDLHFADVALM----ECSDFMQQL------RSFKP------------QSL---------- 646
            |::.:....|..:..:    |...|...|      |..:|            ||:
Mouse   284 KSESVETSLFRKLRAVKSEHETFKFTSDLEEGRLDRGIRPWSCQRCFAHYDVQSILFNINEAMAT 348

  Fly   647 GCAVARRKSSTTLIFPLPPQACSDEFCEEYPHNLMPTPGYWIEC-----SRQKI-TMPTPHTIWD 705
            ..:|.:||:.||          ......:.|..:.|..|    |     |::.: :...|..  |
Mouse   349 RASVGKRKNITT----------GASAASQTPVPVGPAGG----CESPLGSKEDLNSKENPDA--D 397

  Fly   706 ESDSEHEDI----------------------RAGSASDAYLERECSDLYEDDEDSEATPS----- 743
            |.|.:..|:                      ||.|||.:..| .||  :|....|..|.:
Mouse   398 EGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSASFSSGE-SCS--FESSLSSHCTNAGVSVL 459

  Fly   744 --PRKKTTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETL----- 801
              ||:...|..:..::...|.:.:....|.|:|||.||.|||..||:||||.:||::|.:
Mouse   460 EVPRESQPIHREKVKRYIIEHVDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDPRE 524

  Fly   802 --NGRDQFRILVRAGSYT------VHGLIPASCVFADRYNREEVVRSLG-KEV--NLNPPLTLGQ 855
              ..:..:|:..|....|      :...:|::.       |....|.|. |||  .:.|.|::..
Mouse   525 KEGSQFNYRVAFRTSELTTLRGAILEDAVPSTA-------RHGTARGLPLKEVLEYVIPELSIQC 582

  Fly   856 L------PDTPEELLKLDQVFIKSELKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVR 914
            |      |..||:|||||:..:..:.|:|:::.:..|.|||::.:|....|.|:|||.|||.|||
Mouse   583 LRQAANSPKVPEQLLKLDEQGLSFQHKIGILYCRAGQSTEEEMYNNETAGPAFEEFLDLLGQRVR 647

  Fly   915 LRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVF 979
            |:||.||:..||...|.||..|:||.:::.|:||||||||||..::.|:|.||||||||||.:||
Mouse   648 LKGFSKYRAQLDNKTDSTGTHSLYTTYKDFELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVF 712

  Fly   980 LEADNTRFSPACIKSHFLHTFILVRVSARIKHKPTR----YEVSVVTRDEVGAYKPYLWEQSVFE 1040
            .|.....|:|..|:|||.|.|::|:|     |.|..    |.|.|....:|..:.|.:.:...|.
Mouse   713 QEPGALPFTPKNIRSHFQHVFVIVKV-----HNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFP 772

  Fly  1041 KGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDLVMN 1084
            |..:||::||.|::|.|.|::.:.||..|..|||.:.|:||..|
Mouse   773 KSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	9/47 (19%)
		Rap_GAP	893..1074	CDD:280332	82/184 (45%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
Sipa1l2	NP_001074806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..72		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..405		9/48 (19%)
		Rap_GAP	626..806	CDD:366939	82/184 (45%)
		PDZ_signaling	951..1021	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1246
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1360
		SPAR_C	1423..1666	CDD:371778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910