DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad and Ralgapa2

DIOPT Version :9

Sequence 1:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_006499580.1	Gene:	Ralgapa2 / 241694	MGIID:	3036245	Length:	1966	Species:	Mus musculus

Alignment Length:	1414	Identity:	266/1414 - (18%)
Similarity:	436/1414 - (30%)	Gaps:	528/1414 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SSLAQLTDILREWSG------GTKQQQQHHSQQQQQQLQQASRSKAQLNR---------RETLAD 146
            |||.:..:::.|||.      ....:..:..:.....|.:.|..|.:..|         :.|...
Mouse   628 SSLTEWEELITEWSNIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCILEPQKGTAVG 692

  Fly   147 LARSLPWRT-----------STTTDASTGAGGSGGGGCTTYMAPRKRRESSADSGIRSMRSRRDS 200
            .:.||.||:           |.||..:.|.               ::..::......:.||:..|
Mouse   693 RSFSLSWRSHPDVTEPMRFRSATTSGAPGV---------------EKARNTVRQKATAKRSQSIS 742

  Fly   201 NTAEFVRHWNRRESGAVEEQPSV-SVPVVVECSKSASRRGSGESYLSSSRRDSNVAGRVTTPPPP 264
            |....           .|..|:. |||:::.   :.|....|.||.|.|.|.|.|
Mouse   743 NCVHL-----------SEALPATKSVPLLLH---TVSALLPGLSYSSCSHRLSEV---------- 783

  Fly   265 GKYQMTKKRDSLAAP--EFPNFRQEQRPSTSSAGSC-----SDHSM--------PLIST----HS 310
               :..::.:|.||.  ::....|:|.|.:||....     ||.|.        |..||    .|
Mouse   784 ---EEFQQAESTAAADCDYLVVGQQQVPRSSSTSDITERLYSDSSQGYSPMLPHPAFSTTSGDQS 845

  Fly   311 STHHLAHQQVDSACQALPPPTIITSSVTPPA---------TSPTAPKGRRDSQTQCGRVNR---- 362
            |..|        ||.|.|.|.    |..|.|         .|.:.||..::|:   |.|..
Mouse   846 SGPH--------ACTAGPLPL----SRLPSAGQKVEHSQNLSSSEPKSVQESK---GHVTHEHEG 895

  Fly   363 -----RDSKAGVSPERAPRLQ----RLQRQATAFDEG--CLPGGSRRGSQP-----ALSPDP--- 408
                 |.|.:....|....||    |.:::.|:...|  .:.|.|.....|     |...||
Mouse   896 ITMLVRRSSSPAELELKDDLQQAHGRCRQRQTSESTGSDTVVGYSNEAELPVSPWQACEEDPDLS 960

  Fly   409 -PDDCERRTSRRD--SLSPDSASRGGRRDSRTHLSPDRSHERDGSPRRHTLRRQSSSAARSPRSP 470
             |.|....:..|.  .|||..||  ...|||..|:.|.|....|:              .:...|
Mouse   961 TPTDAVADSDARHWLQLSPTDAS--NLTDSRECLADDCSIIAGGN--------------LTGWHP 1009

  Fly   471 DSNSCCSSR------DPSPCSRPQTQTTV--------------EQNQRPAIRRQSTTEEILIARG 515
            ||.:....|      |.:....|:....|              ..|...::..||:....|:...
Mouse  1010 DSAAVLWRRVLGILGDVNNIQSPKIHAKVFGYLYELWYKLAKIRDNLAISLDNQSSPSPPLLIPP 1074

  Fly   516 FRR------QSTT------------EEMIRCRNFRRQ--------------------SSQSDDV- 541
            .|.      ::||            .::|.....|||                    :|:..||
Mouse  1075 LRMFASWLFKATTLPNEYKEGKLQAYKLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDVL 1139

  Fly   542 ------C--RYRGRRDSSAQIIDGTIGTMTVETTSTFFDSSTQTE-----------PS-----PL 582
                  |  |:.........::.|...|......||...::.::|           |:     ||
Mouse  1140 NTIIKNCSPRFFSLGLPGFSMLVGDFITAAARVLSTDMLAAPRSEALTLLGSLVCFPNTYQEIPL 1204

  Fly   583 Y--------------DNNHY------------HEECLRCNS-CGLNL----------TGPNQKRA 610
            .              |..||            ..||.||.: |.|.:          :.|..|.|
Mouse  1205 LQSVPEVSDVVTGAEDVKHYLINILLKNATEEPNECARCIAICSLGVWICEELAQSASHPQVKDA 1269

  Fly   611 -------RRFKNQILCDLHFADVALMECSDFMQQLRSF--KPQSLGCAVARRKSS---TTLIFPL 663
                   .:|.|:|        ||.:.| |.:|.|.|:  |.|....|:.|:.:.   .|:.|.|
Mouse  1270 INVIGVTLKFPNKI--------VAQVAC-DVLQLLVSYWEKLQMFETALPRKMAEILVATIAFLL 1325

  Fly   664 PPQ----------------ACSDEFCEEYP-------------HNLMPTPGYWIE---------- 689
            |..                .|..::|...|             ..|.|:....::
Mouse  1326 PSAEYSSVETDKKFIVSLLLCLLDWCMALPVSALLHPVSTAVLEELHPSRAPLLDYIYRVLHCCV 1390

  Fly   690 CSRQKITMPTPHTIW--DESDSEHE------DIRAGSASDAYLERECSDLYEDDEDSEATPSPRK 746
            |.....|..:.:|:.  |.|.::::      ::|.......:...:..:|...:|:       :|
Mouse  1391 CGSSTYTQQSHYTLTLADLSSTDYDPFLPLANVRNSEPIQYHSSADLGNLLTVEEE-------KK 1448

  Fly   747 KTTIE-----------EQWDQQGAFELI-------SVEQETYEK-YFYGTEHWNYFTSDEDLGP- 791
            :.::|           ...:..|.:.|.       |:..|.::. :..|||    .:|:....|
Mouse  1449 RRSVELIPLTARMVMAHLVNHLGHYPLSGGPAVLHSLVSENHDNAHVEGTE----LSSEVFRSPN 1509

  Fly   792 ---------VILSIKQETLNG---------RDQFRILVR--AGSYTVHGLI-------------- 822
                     .::|..|....|         ....|::||  :|.|:..|.:
Mouse  1510 LQLFVFNDSTLISYLQTPAEGPAGGTSGGSLSDVRVIVRDISGKYSWDGKVLYGPLEGRLAPNGR 1574

  Fly   823 -PASCVFA----------DRYNREE-------VVRSLG---------KEVNLNPP---------- 850
             |:..:..          |.:|.||       ::.::|         .::|||.|
Mouse  1575 NPSFQISGWHHHTCGPQKDLFNGEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSPTPCAMNWD 1639

  Fly   851 -------------------------------LTLGQ-LPDTP----------------------- 860
                                           .:.|| .|..|
Mouse  1640 QEKAIMEVILRQSAQEDEYVQRCNSDSSVTVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRK 1704

  Fly   861 ------------EELLKLDQVFIKSELKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRV 913
                        .||..||....:...|:.|.::.|.|..:..||.|...|..:::|:..||..|
Mouse  1705 NFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILANERGSQAYEDFVAGLGWEV 1769

  Fly   914 RLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVSTLLPYEKHDPQKLQRK-RHIGNDIVCV 977
            .|.....:.|||.. :..||..:.|.....:|::|||||.:|.:..|  .|.:| ||:|||.|.:
Mouse  1770 DLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMPSDSDD--SLTKKLRHLGNDEVHI 1831

  Fly   978 VFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKG 1042
            |:.| .:..:....|.:.|....|::     ...|...:.:::..:.||..:.| |::.::. .|
Mouse  1832 VWSE-HSRDYRRGIIPTAFGDVSIII-----YPMKNHMFFITITKKPEVPFFGP-LFDGAIV-SG 1888

  Fly  1043 PMFREWLLTKIVNGERA-SYSAPKFARMQERTRSQMLEDLVMNLSNHAE 1090
            .:....:....:|..|| ....|.:....|. |:..||.::   .||.|
Mouse  1889 KLLPSLICATCINASRAVKCLIPLYQSFYEE-RALYLEAII---QNHRE 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad	NP_001285176.1	LIM	<583..623	CDD:259829	15/83 (18%)
		Rap_GAP	893..1074	CDD:280332	46/182 (25%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
Ralgapa2	XP_006499580.1	Rap_GAP	1749..1921	CDD:366939	46/183 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910