Protein Alignment rsh and F53A10.2

DIOPT Version :10

• Sequence 1: NP_001285176.1
• Gene: rsh / 32253
• FlyBaseID: FBgn0265597
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001022190.1
• Gene: F53A10.2 / 173502
• WormBaseID: WBGene00018734
• Length: 811
• Species: Caenorhabditis elegans
• Alignment Length: 887
• Identity: 230/887 - (25%)
• Similarity: 380/887 - (42%)
• Gaps: 200/887 - (22%)

  Fly   450 SPRRHTLRRQSSSAARSPRSPDSNSCCSSRDPSPCS-----RPQTQTTVEQNQRPAIRRQSTTEE 509
            :|.||.   .|....||..|..|:|..:|.: ..||     :.:..:.:|.|:....:..: .::
 Worm    29 APLRHA---TSQYNLRSTGSTSSDSSTASEN-DKCSDFSSLKSRRASCIELNKEDEFKVMA-ADK 88

  Fly   510 ILIARGFRRQSTTEEMIRCRNFRRQSSQSDDVCRYRGRRDSSA--QIIDGTIG------------ 560
            :|:|....:.:|:.:.||   :|..|::|........||.|..  ::|.|.:.
 Worm    89 LLMAMENMKHATSSQAIR---WRTTSTESLPGIIKSNRRHSKGPLELIQGLMAKKAAVGRPAKFK 150

  Fly   561 --------TMTVETTSTFFDSSTQTEPSPLYDNNHYHEECLRCNSCGLNLTGPNQKRARRFKNQI 617
                    |:...|.|....|.....|:..:.|...|::        .|.:..:.:..|...|::
 Worm   151 NLGVVGPPTLISSTVSLHEISGFTHNPTSGHQNEQTHQK--------TNGSAVHNQLTRNIMNEV 207

  Fly   618 LCDLHFADVALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEEYPHNLMP 682
            |                                       |.:.|             ||..::|
 Worm   208 L---------------------------------------TKVGP-------------YPQIVLP 220

  Fly   683 TPGYWIECSRQKITMPTPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEATPSPRKK 747
            :.|:|::...|:..|          |.:..::...|.:...|        |.||.|..
 Worm   221 SNGFWMDGVNQQHHM----------DDQVNNMNVNSCARFKL--------ETDETSHC------- 260

  Fly   748 TTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNGRDQFRILVR 812
                                  |.::|:|.||.::|.:|..:||::||::.|.::..|.|||::|
 Worm   261 ----------------------YRRHFFGREHHDFFANDPIVGPLVLSVRTEVISSCDHFRIILR 303

  Fly   813 AGSYTVHGLIPASCVFADRYNREEVVRSLGKEVNLN--PPLTLGQLPDTPEELLKLDQVFIKSEL 875
            ....|:|.::.|:.: |||.:...:.:.|.:|:...  .|:.   .|...|.:::.|:..:.:..
 Worm   304 TRKGTIHEIVSATAL-ADRPSASRMAKLLCEEITTEQFSPVA---FPGGSELIVQYDEHVLTNTY 364

  Fly   876 KVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTN 940
            |.|||:.|..|.||||:..|...||.|||||:::||.|:|.||.||:|||||.|:.||..||::.
 Worm   365 KFGVIYQKGGQTTEEQLFGNPHGSPAFDEFLSMIGDSVQLNGFQKYRGGLDTAHNQTGHQSVFSE 429

  Fly   941 WRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRV 1005
            ::|.||||||||:|||...|.|:||||||||||||.::|.|| ||.|:|..|.|:|||.:::|:.
 Worm   430 FKNREIMFHVSTMLPYTIGDAQQLQRKRHIGNDIVAIIFQEA-NTPFAPDMIASNFLHAYVVVQP 493

  Fly  1006 SARIKHKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQ 1070
            ...:..: .||.|||..||:|..:.|.|...|:|::|..||.:||||::|.|.|:|.:.|||::.
 Worm   494 IDALTDR-VRYRVSVAARDDVPFFGPTLPTPSIFKRGQDFRNFLLTKLINAENAAYKSSKFAKLA 557

  Fly  1071 ERTRSQMLEDLVMNLSNHAETGQIPKPYRRGSWRPIGEDEYIKMLHARVLDNNTHHEQQQQLLLQ 1135
            |||||.:|:.|...|...||....|......|.   ||........:...........::..:.:
 Worm   558 ERTRSSLLDGLHATLRERAEFYATPLLESTSSG---GESAATTSSSSNSYGGGILSSVKKAFIGR 619

  Fly  1136 QQHMQHTQHMQHLPSHNICCYCNNNATELHTAGAIH-----NNNDNNNTTTTTTFTH---RHNNN 1192
            .:.:  :|...|:|               |.|..|:     ..:.::.:::|:..||   |....
 Worm   620 SRSV--SQEASHVP---------------HRAATINVTSRPKKSISSTSSSTSARTHSPIRDEEV 667

  Fly  1193 NNNYSEQ---QQQQLPQQQQHDSQQQQQLLQPQQHQLLHQLQLSTSSLTHTSCCAMLHLCARHSH 1254
            ...|.::   ..|:.| ..:|||....:.:...      ::...|.:.:.|.|....|:.|.|..
 Worm   668 VKPYRKEWEISSQESP-DNEHDSDTGMESMSST------EMSGQTRASSCTFCVDDFHVAANHQS 725

  Fly  1255 ---MRPSSPLLDSVRDQFEDYDQLAKDFTRVFLNEEPSCLTN 1293
               .|..:..:|..|.|.|.:|         .|.:..||.|:
 Worm   726 SDAKRLETLCVDVTRLQNEKHD---------LLRQNVSCKTD 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rsh	NP_001285176.1	PHA03309	<207..539	CDD:165564	21/93 (23%)
		LIM	<583..623	CDD:259829	6/39 (15%)
		Rap_GAP	893..1074	CDD:460463	93/180 (52%)
		BTB_POZ	1289..>1344	CDD:453885	3/5 (60%)
		BTB	<1467..1526	CDD:197585
		BACK	1531..1603	CDD:475122
F53A10.2	NP_001022190.1	Rap_GAP	382..561	CDD:460463	93/180 (52%)