Protein Alignment rsh and rap1gap2

DIOPT Version :10

• Sequence 1: NP_001285176.1
• Gene: rsh / 32253
• FlyBaseID: FBgn0265597
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_017946981.1
• Gene: rap1gap2 / 100495015
• XenbaseID: XB-GENE-6050621
• Length: 734
• Species: Xenopus tropicalis
• Alignment Length: 639
• Identity: 189/639 - (29%)
• Similarity: 306/639 - (47%)
• Gaps: 128/639 - (20%)

  Fly   584 DNNHYHEECLRCNSCGLNLTGPNQKRARRFKNQILCDLHFADVAL--------------MECSDF 634
            |..|..:..:|.....:.|...::|:.|..:.|.|.:.  ::|.|              |:.::|
 Frog     6 DRMHSKKAGIRAAVVLIGLLHKSRKQNRERRKQELSNT--SEVTLPERPASPPATAPPTMKSAEF 68

  Fly   635 MQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEE---YPHNLMPT-PGYWIECSRQKI 695
            .:.|...:...|....:..:.:.....|.|   ..:|..|:   ||..::|. .|||||
 Frog    69 FEMLEKMQVPKLEEQKSGSQKNKEDYIPYP---SIEEILEKDMPYPLIILPQFGGYWIE------ 124

  Fly   696 TMPTPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEATPSPRKKTTIEEQWDQQGAF 760
                          :.|::...::||:.:   |     |||:...:||     |...:.:.:|:
 Frog   125 --------------DPENVSTPTSSDSSI---C-----DDEEEPISPS-----TYGYKLEYKGS- 161

  Fly   761 ELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNGRDQFRILVRAGSYTVHGLIPAS 825
                  ...|.|:|.|.:|.|::.:...||.:|||:|.|..:|.:..||::|:.:.|:|..||.|
 Frog   162 ------ARAYRKHFMGKDHLNFYCTASSLGNLILSVKCEESDGIEYLRIILRSKAKTLHERIPLS 220

  Fly   826 CVFADRYNREEVVRSLGKE---VNLNPPLTLGQLPDTPEELLKLDQVFIKSELKVGVIFVKEDQY 887
             .|:...:..::.::|..:   :..||.|    .|...:.::..|:..|.:..|.|||:.|..|.
 Frog   221 -GFSKLPSIPQIAKALCDDATGLKFNPVL----YPKASQLIVAYDEHEINNTFKFGVIYQKYKQT 280

  Fly   888 TEEQILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFSVYTNWRNIEIMFHVST 952
            :||::..|:|.||.|.||:.||||.|.|:.|..::||||..|..||..|:||.:|..||||||||
 Frog   281 SEEELFGNSEESPAFKEFMDLLGDAVLLQDFKGFRGGLDVAHGQTGTESIYTVFREKEIMFHVST 345

  Fly   953 LLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFILVRVSARIKHKP---- 1013
            .||:.:.|.|:||||||||||||.::|.| :||.|.|..|.|:|||.:|:|:|     ..|
 Frog   346 KLPFTEGDTQQLQRKRHIGNDIVAIIFQE-ENTPFVPDMIASNFLHAYIVVQV-----ENPEADI 404

  Fly  1014 TRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQML 1078
            |.|:|||..|::|.::.|.|....||.|...|||:||||::|.|.|...:.|||::::|||:.:|
 Frog   405 TMYKVSVTAREDVPSFGPPLPNPPVFHKNSEFREFLLTKLINAEHACCKSDKFAKLEDRTRAALL 469

  Fly  1079 EDLVMNLSNHAET--GQIPKPYRRGSWRPIGEDEYIKMLHARVLDNNTHH---EQQQQLLLQQQH 1138
            ::|..:|..|.:.  |..|:           ||:         |:|..|.   |..::.:..:.|
 Frog   470 DNLHDDLHVHTQAMLGLGPE-----------EDK---------LENGAHGGFLESFKRAIRVRSH 514

  Fly  1139 MQHT------QHMQHLPSHNICCYCNNNATELHTAGAIHNNNDNNNTTTTTTFT 1186
            ...|      :|.....|.::            :.|.:|.:.:    .|.|||:
 Frog   515 SMETMVGSQKKHQSAGISGSL------------SGGIVHTSAE----ITKTTFS 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rsh	NP_001285176.1	PHA03309	<207..539	CDD:165564
		LIM	<583..623	CDD:259829	8/38 (21%)
		Rap_GAP	893..1074	CDD:460463	90/184 (49%)
		BTB_POZ	1289..>1344	CDD:453885
		BTB	<1467..1526	CDD:197585
		BACK	1531..1603	CDD:475122
rap1gap2	XP_017946981.1	Rap_GAP	286..465	CDD:460463	90/184 (49%)