Protein Alignment rsh and rap1gap2b

DIOPT Version :10

• Sequence 1: NP_001285176.1
• Gene: rsh / 32253
• FlyBaseID: FBgn0265597
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_068071862.2
• Gene: rap1gap2b / 100170821
• ZFINID: ZDB-GENE-080722-11
• Length: 739
• Species: Danio rerio
• Alignment Length: 888
• Identity: 223/888 - (25%)
• Similarity: 365/888 - (41%)
• Gaps: 236/888 - (26%)

  Fly   593 LRCNSCG-------LNLTGPNQKRARR---------FKNQILCDLHFADVALMECSDFMQQLRSF 641
            :||...|       :.|...::||..|         :|.::|.   .::|.|.:|.       ..
Zfish     8 VRCRRAGVRAAAALIGLLHRSRKRCERRRLTEGDSQWKQELLT---ISNVPLSDCP-------HS 62

  Fly   642 KPQSLGCAVAR--------RKSSTTLIFPLPPQACSDEFC------------EEYPHNLMPT-PG 685
            .|::...||..        :....:.:..:.||...|::.            |.||..::|. .|
Zfish    63 PPRTAPPAVKSTQFFDMLDKMEQVSEVEEMRPQRVKDDYIPYPRIEEVLQRGEPYPQVILPQFGG 127

  Fly   686 YWIECSRQKITMPTPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEATPSPRKKTTI 750
            |||                       ||..|.:|...:....|.|   ||||.        :.:.
Zfish   128 YWI-----------------------EDPEAPAAIANWENGFCDD---DDEDG--------RNSG 158

  Fly   751 EEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNGRDQFRILVRAGS 815
            |..:..:..|.:     ..|.|:|.|.||.|::.:..:.|.::||::.|.:..::...|::||.|
Zfish   159 EYGYKLESNFAI-----RAYRKHFLGREHLNFYCTASNHGNLVLSLRHEEVKEQEYLHIILRAPS 218

  Fly   816 YTVH------GLIPASCVFADRYNREEVVRSLGKEV---NLNPPLTLGQLPDTPEELLKLDQVFI 871
            .|::      ||.....|       .::.:.|.:::   ..:|.|    .|...:.::..|:..:
Zfish   219 KTIYDRISLTGLTELPSV-------PQLAKLLCEDIVGLRFSPVL----YPKGSQLIVNYDEHEL 272

  Fly   872 KSELKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLTGLFS 936
            .:..|.|||:.|..|.:||::..|:|.:|.|.|||.:|||.|:|:.|..::||||..|..||..|
Zfish   273 NNTFKFGVIYQKFGQTSEEELFGNSEETPAFTEFLRVLGDCVQLQDFKGFRGGLDVSHGQTGSQS 337

  Fly   937 VYTNWRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFLHTFI 1001
            |||.::..|:|||:||.|||.:.|.|:||||||||||||..||.| :.|.|.|..|.|:|||.:|
Zfish   338 VYTVFKGQELMFHISTKLPYIEGDTQQLQRKRHIGNDIVAAVFQE-EATPFVPDMIASNFLHAYI 401

  Fly  1002 LVRVSARIKHKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKF 1066
            ||:|......:.| |:|||..|::|..:.|.|....:|:|||.|||:||||::|.|.|.|.:.:|
Zfish   402 LVQVENSGTDEAT-YKVSVTAREDVPQFGPPLPNPPIFKKGPEFREFLLTKLINAELACYRSNRF 465

  Fly  1067 ARMQERTRSQMLEDLVMNLSNHAETGQIPKPYRRGSWRPIGEDEYIKMLHARVLDNNTHHEQQQQ 1131
            |:::||||:::|:    ||.|     ::.|..:.....|:..||       ..::|..|
Zfish   466 AKLEERTRTELLD----NLHN-----ELQKRTQSMLGHPLNPDE-------ERMENGGH------ 508

  Fly  1132 LLLQQQHMQHTQHMQHLPSHNICCYCNNNATELHTAGAIHNNNDNNNTTTTTTFTHRHNNNNNNY 1196
                ...::..:....:.||::                           .|...||:|    ...
Zfish   509 ----GGILESIKRAMRVRSHSM---------------------------ETMVGTHKH----GRC 538

  Fly  1197 SEQQQQQLPQQQQHDSQQQQQLLQPQQHQLLHQLQLSTSSLTHTSCCAMLHLCARHSHMRPSSPL 1261
            |......:|                        ..||..||||:|..|          .:.|||:
Zfish   539 SPAAGAGVP------------------------TSLSGVSLTHSSSEA----------AKNSSPV 569

  Fly  1262 LDSVRDQFED-YDQLAKDFTRVF--LNEEPSCLTNAHLFDVVFLVGQSKQKARFIGVRAILGVRS 1323
            ..|.:...:. ..:.:..|.|::  ::|:|...|.:.|.|         |::...|
Zfish   570 TSSAKSPLKSPVKRRSGLFPRLYTSMDEQPERHTRSVLCD---------QRSLDCG--------- 616

  Fly  1324 RVFQEMLYGIQTGFGSPQI-----PVAEIFARPAPSLVSPQNQKPKS-NNYLTVPDS-DSIRPKS 1381
            .:.||:.....:...||:|     |..::.....|..:|..:....| ::....|:: :...|..
Zfish   617 HLSQEVKSETSSNPSSPEILNNERPSLKLQEVSGPPDISRSSSSTSSFSSAAGEPETVEEKEPSG 681

  Fly  1382 VPSSPMVKRAFSRLGTITAGWGRSI---------RNKNTNQLN 1415
            |..||.:...|..|.|.....|..:         |||.:.:.|
Zfish   682 VQISPSLSPVFGSLTTDGQAAGAPVIMCRSPTDFRNKTSPRSN 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rsh	NP_001285176.1	PHA03309	<207..539	CDD:165564
		LIM	<583..623	CDD:259829	9/45 (20%)
		Rap_GAP	893..1074	CDD:460463	90/180 (50%)
		BTB_POZ	1289..>1344	CDD:453885	10/59 (17%)
		BTB	<1467..1526	CDD:197585
		BACK	1531..1603	CDD:475122
rap1gap2b	XP_068071862.2	None