Protein Alignment CG12716 and SPINK14

DIOPT Version :10

• Sequence 1: NP_572845.1
• Gene: CG12716 / 32248
• FlyBaseID: FBgn0030439
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001001325.1
• Gene: SPINK14 / 408187
• HGNCID: 33825
• Length: 97
• Species: Homo sapiens
• Alignment Length: 959
• Identity: 182/959 - (18%)
• Similarity: 296/959 - (30%)
• Gaps: 365/959 - (38%)

  Fly    68 TTIINNNSNNSGLPMSEHSAFSPYARPSSLTSQDSKQYHQTPHVVL----RPEPR---LALPPL- 124
            |.::.||.:     :|...:|.|.         |.||:.......|    :|:||   |.|..|
Human    15 TAVLTNNFH-----LSSGESFLPL---------DRKQFDVVVESCLEGICKPDPRIFQLCLQRLS 65

  Fly   125 LQRQE-------GSDSNI--SKKIRSKRRERPRS--------VGL-LDLGVASL-----TYLEPE 166
            ||..|       ||:..:  |..|.:.:.:||.:        :|. |.|||.:.     |...|:
Human    66 LQPSEAIFLDDLGSNLKVAASLGIHTIKVDRPETAVKELEALLGFPLHLGVPNTRPVRKTMAIPQ 130

  Fly   167 SNDHDDKSADRGSSSSTSSHHHNHSHLMSPPIATWSATPIKMVGSQDSWGTPPHYRSSLNSN--Y 229
              |..:|                   .:...:.|.|..|::::........|.:|....:..  .
Human   131 --DALEK-------------------YLKGLLGTHSTGPMELLQFDHGQSNPTYYIRLADRQLVL 174

  Fly   230 RDSPANSRNTSA-------RSRLSVSSAQSPHCFLPTT----RDSSPRSIP-------------S 270
            |..|:.:...||       |...::::|..|   :||.    .|||....|             .
Human   175 RKKPSGTLLPSAHAIEREFRIMKALANAGVP---VPTVLDLCEDSSIIGTPFYLMEYCPGIIYKD 236

  Fly   271 PSLVPMRPDSSSDI--TINE----LHHSPLSHTG---------STPEPTEIISK-----PTSKVP 315
            |||..:.|.....|  .:|:    :|...|..|.         ..|...:..:|     .||.:|
Human   237 PSLPGLEPSRREAIYTAMNQVLCRIHSVDLQATSLDSFGKQGDYIPRQVQTWTKQYRAAETSSIP 301

  Fly   316 S---------------RRASYSTG---------YPNH-ETFAPIRWVKETDVDDPLS-------- 347
            :               :|.:...|         :|.. |..|.:.|...| :.||.:
Human   302 AMERLIQWLPLHLPRQQRTTLVHGDFRLDNLIFHPEKAEVLAVLDWELST-LGDPFADVAYSCLA 365

  Fly   348 --IPTMSPI--GSSGSSEANIGMISSRSAPMSKMPSVEK-------------LDNRH-------- 387
              :|:..||  |........:|           :|:||:             :||.:
Human   366 YYLPSSFPILRGFRDQDVTKLG-----------IPTVEEYFRMYCLNMGIPPIDNWNFYMAFSFF 419

  Fly   388 ---SSIRGYNNRSCRRTVLSGLDRNANH-------------SPNGIYVRRSRSKDDRPSLSYMSF 436
               :.::|...||......|...:.:..             :..|..|.:........|.||.::
Human   420 RVAAILQGVYKRSLTGQASSATAQQSGKLTESMAELAWDFATKEGFRVFKEMPATKTLSRSYHAW 484

  Fly   437 NGMDQQNVSPPRTASIPI-FMSQESVSMQSPMNSPVNHSMSHVARNDRSQSNHNLSG--EELYKR 498
            .|        ||:...|. .....:|:..||         ||.|:.....|...||.  .:||::
Human   485 AG--------PRSPRTPKGVRGHSTVAAASP---------SHEAKGGLVISPEGLSPAVRKLYEQ 532

  Fly   499 FQQISLSHVQTLNIVADKLSEDARRGDEPVSRNRLSQLDFASFIITSPHPIL------TKGKSLF 557
            ..|.....|..|               ||..:...:..|     ..||.|::      .|.:.|
Human   533 LVQFIEQKVYPL---------------EPELQRHQASAD-----RWSPSPLIEDLKEKAKAEGL- 576

  Fly   558 YNAVLPRQSLP-----------DYPVTLMIAPCSQYAPLMRKTESNHFGLP--GFLEI------E 603
            :|..||.::.|           :|.....:...|.||     :|..:...|  |.:||      |
Human   577 WNLFLPLETDPEKKYGAGLTNVEYAHLCEVMGMSLYA-----SEIFNCSAPDTGNMEILVRYGTE 636

  Fly   604 DH---------DGAIRQFLYDTGTQ--NLDGRN--------------------TKVIAMPRLNLC 637
            :.         :|.||.....|..|  :.|..|                    |..|..||..||
Human   637 EQKARWLVPLLEGRIRSCFAMTEPQVASSDASNIEASIKEEDGCYVINGHKWWTSGILDPRCKLC 701

  Fly   638 SFHSLAAHQLNQRMDRTN-----HEELVSFILLQV----LQALKMLQGEGVESL-----STNFKE 688
            .|           |.:|:     |:: .|.:|:.:    :..::.|...|:|..     ...||:
Human   702 VF-----------MGKTDPQAPRHQQ-QSMLLVPMDSPGITVIRPLSVFGLEDPPGGHGEVRFKD 754

  Fly   689 FLLAYRYPNVNSSYNEFPRLLFLPETLGAEIESG--GDELVGLCR----YALRALCTLLHHKMDG 747
                .|.|..|         :.|....|.||..|  |...:..|.    |:.|||..:....|.
Human   755 ----VRVPKEN---------ILLGPGRGFEIAQGRLGPGRIHHCMRLIGYSERALALMKTRVMS- 805

  Fly   748 KAPPIQLRSRFSRALSACAVLLQE--------DKSNSLT-KAKNVMELA 787
                   |:.|.:.|.....:|.:        :::..|. ||.::|::|
Human   806 -------RTAFGKPLVEQGTILADIARSRVEIEQARLLVLKAAHLMDVA 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12716	NP_572845.1	KAZAL_FS	146..192	CDD:238052	11/59 (19%)
SPINK14	NP_001001325.1	KAZAL_PSTI	53..97	CDD:238648	12/43 (28%)