DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12716 and CG1077

DIOPT Version :9

Sequence 1:	NP_572845.1	Gene:	CG12716 / 32248	FlyBaseID:	FBgn0030439	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_649617.1	Gene:	CG1077 / 40751	FlyBaseID:	FBgn0037405	Length:	730	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	103/443 - (23%)
Similarity:	151/443 - (34%)	Gaps:	154/443 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PMQIQYVDYQP---------NCQPGGVPVCATNGTDSFYFENHCRL-----EAANMKMLFQHGTE 128
            |.:..||...|         :|..|..|||......|..|.|.|.|     :..|...:..:|.
  Fly   268 PARKPYVVVPPKSKRRIPTKSCVFGNEPVCGNLRGQSRTFSNVCELMEFSQKVGNAWTIAHNGA- 331

  Fly   129 LEPTEMERCLPNCQTMKCTQVERPVCALAEIGGAIPQTFANECEMRKHEC-HTKQVLRILHTGPC 192
                 ..||...|.|     |.:|:||..   ..|..|..|||.:.:..| ..|.:.::.|.|.|
  Fly   332 -----CRRCDKTCPT-----VYQPICATR---NGINHTIVNECYLERVRCKDPKSIWKLSHKGEC 383

  Fly   193 QTPTKSGRKKKLRRNKKKRPTLNASISKFATIPKKVYIMLATPAPRSSSTTPRPFFSTTTTRITT 257
            .....:.|  .:....|.|||        :.:|..:|        ..|:||||..|.....|.||
  Fly   384 AKSVSNPR--HIYSTGKSRPT--------SLVPSVLY--------GKSTTTPRSRFRKPVRRFTT 430

  Fly   258 TARMRPTKP-----------TSTSPS------PMRFQQL-------MNVANPMVSVSQAIDAY-- 296
            |  ..||.|           ::||||      .:|..:|       :..::....:|...||:
  Fly   431 T--RTPTTPYKPRQLAMTNFSATSPSLETNNRKIRKIELAAAGFSGLGASSGSNFLSSEEDAFWS 493

  Fly   297 ------------NVYNI-----PDVGHDYGEITDSSLSMFLPEVGRVTEPYSVPPRTTTKTTSTT 344
                        ||..:     ..:..::||  ...||.::           ||||.|:..::||
  Fly   494 SDDSWLVQKTLDNVKGLLGNKPTSLKKEHGE--KYPLSYWI-----------VPPRQTSTISTTT 545

  Fly   345 RA---------------------------------------TT---TSTTTPKPVLATSRIITPL 367
            .|                                       ||   |::|||.|...|...||..
  Fly   546 AAPPAKLPAILSMASTELLNLDFGNPSSAYEEADHEAMLMLTTKEGTTSTTPVPSTTTPPNITEP 610

  Fly   368 STSTMQSFLSVRMPSTTEMVEESTT---ENPEASTQAFSTT----QKSTATAQ 413
            ||:.:.:.:.|...|...:.|:|||   |..:.:|...|:|    |.||..|:
  Fly   611 STTELPTSVDVASDSAETVSEDSTTDFGETTDPTTSNDSSTSDAPQSSTTEAE 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12716	NP_572845.1	KAZAL_FS	146..192	CDD:238052	13/46 (28%)
CG1077	NP_649617.1	KAZAL_FS	86..131	CDD:238052
		KAZAL_FS	149..193	CDD:294071
		KAZAL	335..383	CDD:197624	16/55 (29%)
		Podoplanin	<612..688	CDD:283467	15/52 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10913
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100