Protein Alignment hec and Glp2r

DIOPT Version :10

• Sequence 1: NP_572843.2
• Gene: hec / 32246
• FlyBaseID: FBgn0030437
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_068620.1
• Gene: Glp2r / 60432
• RGDID: 620270
• Length: 550
• Species: Rattus norvegicus
• Alignment Length: 450
• Identity: 117/450 - (26%)
• Similarity: 211/450 - (46%)
• Gaps: 76/450 - (16%)

  Fly    64 LPENFSPVPRYLENAAMNEG----------VIDMRNVDEELAEKEELMATVVSATMATNQKE--- 115
            :||...|||.:.:...:..|          ::.::.|...|.::        :.....|.||
  Rat    28 IPEAQGPVPLHSQQMRLLWGPGRPFLALLLLVSIKQVTGSLLKE--------TTQKWANYKEKCL 84

  Fly   116 ----NRL---FCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKF--LAHKTCLENGSWYRHPV 171
                |||   ||...||.|:|||.:..|.| |..||.::..:|.:.  .|::.||..|:|.....
  Rat    85 EDLHNRLSGIFCNGTFDRYVCWPHSYPGNV-SVPCPSYLPWWNAESPGRAYRHCLAQGTWQTREN 148

  Fly   172 SNQTWSNYTNCVDYEDLEFRQFINE---------LYVKGYALSLLALLISIIIFLGFKSLRCTRI 227
            :...|.:.:.|  .|:..|||.::.         :|..||::||::|.:::.:||..:.|.|||.
  Rat   149 TTDIWQDESEC--SENHSFRQNVDHYALLYTLQLMYTVGYSVSLISLFLALTLFLFLRKLHCTRN 211

  Fly   228 RIHVHLFASLACTCVAWILWYRLVVERSET------------IAENPLWCIGLHLVVHYFMLVNY 280
            .||::||||.....:| :|...:|...|.:            ::|..:.|..:.:::|||:..|:
  Rat   212 YIHMNLFASFILKVLA-VLVKDMVSHNSYSKRPDDESGWMSYLSETSVSCRSVQVLLHYFVGTNH 275

  Fly   281 FWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPIPIAIVYGLAR-HFSSPDNKHCWITD-SL 343
            .|:..|||:||.:|......:..:...::|:.|..|:...|.:|.|| |.   :|..||.|: :|
  Rat   276 LWLLVEGLYLHTLLEPTVFPERRLWPKYLVVGWAFPMLFVIPWGFARAHL---ENTRCWATNGNL 337

  Fly   344 YL-WIFSVPITLSLLASFIFLINVLRVIVRKLHPQSAQPAPLAIR----KAVRATIILVPLFGLQ 403
            .: ||...|:.|.:..:|...:.:|::::.||....     :..|    :..::|::|:||.|:.
  Rat   338 KIWWIIRGPMLLCVTVNFFIFLKILKLLISKLKAHQ-----MCFRDYKYRLAKSTLLLIPLLGVH 397

  Fly   404 HFLLPYRPDAGTQLDHFYQ----MLSVVLVSLQGFVVSFLFCFANHDVTFAIRTLLNKLL 459
            ..|..:.||  .|:..|.:    .:.:.|.|:.||:|:..:.|||.:|...:|....:.|
  Rat   398 EVLFTFFPD--DQVQGFSKRIRLFIQLTLSSVHGFLVALQYGFANGEVKAELRKSWGRFL 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_572843.2	HRM	118..183	CDD:397086	21/69 (30%)
		7tmB1_NPR_B4_insect-like	191..457	CDD:320388	79/297 (27%)
		TM helix 1	193..218	CDD:320388	7/33 (21%)
		TM helix 2	227..249	CDD:320388	8/21 (38%)
		TM helix 3	266..293	CDD:320388	10/26 (38%)
		TM helix 4	305..325	CDD:320388	4/19 (21%)
		TM helix 5	341..370	CDD:320388	7/30 (23%)
		TM helix 6	385..412	CDD:320388	7/30 (23%)
		TM helix 7	419..444	CDD:320388	7/28 (25%)
Glp2r	NP_068620.1	HRM	93..162	CDD:397086	21/71 (30%)
		7tmB1_GLP2R	175..453	CDD:320394	77/288 (27%)
		TM helix 1	177..202	CDD:320394	7/24 (29%)
		TM helix 2	211..233	CDD:320394	8/22 (36%)
		TM helix 3	261..288	CDD:320394	10/26 (38%)
		TM helix 4	300..320	CDD:320394	4/19 (21%)
		TM helix 5	336..365	CDD:320394	7/28 (25%)
		TM helix 6	379..406	CDD:320394	6/26 (23%)
		TM helix 7	415..440	CDD:320394	6/24 (25%)