DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hec and Pth1r

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_038937952.1	Gene:	Pth1r / 56813	RGDID:	3442	Length:	600	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	116/370 - (31%)
Similarity:	187/370 - (50%)	Gaps:	43/370 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 CPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAHKTCLENGSWYRHPVSNQTWSNYTNCVD 184
            |...:|..:|||....|.|::..|||::..||.|..|::.|..||||...|..|:||:||:.|:.
  Rat   117 CLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLK 181

  Fly   185 YEDLEFRQ-----FINELYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLACTCVA- 243
            :...|.|:     .:..:|..||::||.:|.::::|...|:.|.|||..||:|:|.|......:
  Rat   182 FMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASI 246

  Fly   244 ----WILWYRLVVERSETIAENPLWCI---------------GLHLVVH---YFMLVNYFWMFCE 286
                .:|:....::.:|.:.|..|..|               |..:.|.   ||:..||:|:..|
  Rat   247 FVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVE 311

  Fly   287 GLHLHLVLVVVFVKDTIVMRWFIVISWFSP-IPIAIVYGLARHFSSPDNKHCW-ITDSLYLWIFS 349
            ||:||.::.:.|..:...:..|.:..|..| :.:|:..|:....:   |..|| ::.....||..
  Rat   312 GLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLA---NTGCWDLSSGHKKWIIQ 373

  Fly   350 VPITLSLLASFIFLINVLRVIVRKLHPQSAQPAPL--AIRKAVRATIILVPLFGLQH---FLLPY 409
            |||..|::.:||..||::||:..||...:|.....  ..||.:|:|::||||||:.:   ..|||
  Rat   374 VPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPY 438

  Fly   410 RPDAGT--QLDHFYQMLSVVLVSLQGFVVSFLFCFANHDVTFAIR 452
            ...:||  |:...|:||   ..|.|||.|:.::||.|.:|...||
  Rat   439 TEVSGTLWQIQMHYEML---FNSFQGFFVAIIYCFCNGEVQAEIR 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	26/64 (41%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	74/251 (29%)
Pth1r	XP_038937952.1	HRM	114..179	CDD:397086	25/61 (41%)
		7tm_GPCRs	193..485	CDD:421689	88/294 (30%)
		TM helix 1	195..220	CDD:410628	7/24 (29%)
		TM helix 2	229..251	CDD:410628	5/21 (24%)
		TM helix 3	291..318	CDD:410628	11/26 (42%)
		TM helix 4	330..350	CDD:410628	4/19 (21%)
		TM helix 5	365..394	CDD:410628	11/28 (39%)
		TM helix 6	411..438	CDD:410628	11/26 (42%)
		TM helix 7	447..472	CDD:410628	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810