Protein Alignment hec and crhr1

DIOPT Version :10

• Sequence 1: NP_572843.2
• Gene: hec / 32246
• FlyBaseID: FBgn0030437
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: XP_696346.3
• Gene: crhr1 / 567940
• ZFINID: ZDB-GENE-081231-1
• Length: 430
• Species: Danio rerio
• Alignment Length: 384
• Identity: 123/384 - (32%)
• Similarity: 191/384 - (49%)
• Gaps: 55/384 - (14%)

  Fly   100 LMATVVSA--------TMATNQKENRLFCPLNFDGY-LCWPRTPAGTVLSQYCPDFVEG--FNRK 153
            |::|.::|        |.:.......|||..:.||. .||||:.||.|:|:.||:...|  :|..
Zfish    31 LLSTNLTARTLILWNQTSSPTTNSTGLFCNTSIDGIGTCWPRSSAGEVVSRPCPESFLGVRYNTT 95

  Fly   154 FLAHKTCLENGSWYRHPVSNQTWSNYTNCVDYEDLEFRQ--------FINELYVKGYALSLLALL 210
            ...::.||.||:|.:.       .||:.|.:..:.|.:.        .||.|   |:.:||.|||
Zfish    96 NNVYRECLANGTWAKK-------GNYSQCQEILNEEKKSKLHYHIAVIINYL---GHCISLGALL 150

  Fly   211 ISIIIFLGFKSLRCTRIRIHVHLFASLACTCVAWILWYRLVVE---RSETIAENPLWCIGLHLVV 272
            ::.|:|:..:|:||.|..||.:|..:.......|     .||:   ..|....|.:||..:....
Zfish   151 VAFILFMRLRSIRCLRNIIHWNLITAFILRNATW-----FVVQLTMNPEVHESNVIWCRLVTAAY 210

  Fly   273 HYFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPIPIAIVYGLARHFSSPDNKHC 337
            :||.:.|:||||.||.:||..:|:.:..|.:....||.|.|..|.||.:.:.:.:.:.  ||:.|
Zfish   211 NYFHVTNFFWMFGEGCYLHTAIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYY--DNEKC 273

  Fly   338 WI-------TDSLYLWIFSVPITLSLLASFIFLINVLRVIVRKLHPQSAQPAPLAIRKAVRATII 395
            |.       ||    :|:..|:.|.||.:||||.|::|:::.||. .|.....:..||||:||::
Zfish   274 WFGKRAGIYTD----YIYQGPMILVLLINFIFLFNIVRILMTKLR-ASTTSETIQYRKAVKATLV 333

  Fly   396 LVPLFGLQHFLLPYRP--DAGTQLDHFYQMLSVVLVSLQGFVVSFLFCFANHDVTFAIR 452
            |:||.|:.:.|....|  |..:|:...|  .:..|.|.|||.||..:||.|.:|..|:|
Zfish   334 LLPLLGITYMLFFVNPGEDEISQIVFIY--FNSFLESFQGFFVSVFYCFLNSEVRSAVR 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_572843.2	HRM	118..183	CDD:397086	24/67 (36%)
		7tmB1_NPR_B4_insect-like	191..457	CDD:320388	93/282 (33%)
		TM helix 1	193..218	CDD:320388	11/24 (46%)
		TM helix 2	227..249	CDD:320388	4/21 (19%)
		TM helix 3	266..293	CDD:320388	11/26 (42%)
		TM helix 4	305..325	CDD:320388	7/19 (37%)
		TM helix 5	341..370	CDD:320388	12/28 (43%)
		TM helix 6	385..412	CDD:320388	12/28 (43%)
		TM helix 7	419..444	CDD:320388	10/24 (42%)
crhr1	XP_696346.3	HormR	55..126	CDD:214468	26/77 (34%)
		7tmB1_CRF-R1	131..395	CDD:320561	93/277 (34%)
		TM helix 1	133..158	CDD:320561	11/27 (41%)
		TM helix 2	167..189	CDD:320561	6/26 (23%)
		TM helix 3	204..230	CDD:320561	10/25 (40%)
		TM helix 4	243..263	CDD:320561	7/19 (37%)
		TM helix 5	280..309	CDD:320561	13/32 (41%)
		TM helix 6	323..350	CDD:320561	11/26 (42%)
		TM helix 7	357..382	CDD:320561	10/26 (38%)