Protein Alignment hec and Calcrl

DIOPT Version :9

• Sequence 1: NP_001285174.1
• Gene: hec / 32246
• FlyBaseID: FBgn0030437
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_061252.2
• Gene: Calcrl / 54598
• MGIID: 1926944
• Length: 463
• Species: Mus musculus
• Alignment Length: 349
• Identity: 133/349 - (38%)
• Similarity: 201/349 - (57%)
• Gaps: 9/349 - (2%)

  Fly   113 QKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAHKTCLENGSWYRHPVSNQTWS 177
            |:...|:|...:||:|||....|||...|||||:.:.|:......|.|.::|.|:|||.||:||:
Mouse    57 QQAEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTWT 121

  Fly   178 NYTNCVDYEDLEFRQFINELY--VKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLACT 240
            |||.|.:....:.:..:|..|  :.|:.||:.:|:||:|||..||||.|.||.:|.:||.|..|.
Mouse   122 NYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICN 186

  Fly   241 CVAWILWYRLVVERSETIAENPLWCIGLHLVVHYFMLVNYFWMFCEGLHLH-LVLVVVFVKDTIV 304
            .:..|:....|......:|.||:.|.....:..|.|..|||||.|||::|| |::|.||.:...:
Mouse   187 SIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHL 251

  Fly   305 MRWFIVISWFSPIPIAIVYGLARHFSSPDNKHCWI-TDSLYLWIFSVPITLSLLASFIFLINVLR 368
            | |:..:.|..|:..|.::.:||.....||  ||| :|:..|:|...||..:||.:..||:|::|
Mouse   252 M-WYYFLGWGFPLLPACIHAIARSLYYNDN--CWISSDTHLLYIIHGPICAALLVNLFFLLNIVR 313

  Fly   369 VIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPDAGTQLDHFYQMLSVVLVSLQG 433
            |::.||.......:.|.: ||||||:|||||.|::..|.|:||: |...:..|..:..:|:..||
Mouse   314 VLITKLKVTHQVESNLYM-KAVRATLILVPLLGIEFVLFPWRPE-GKVAEEVYDYVMHILMHFQG 376

  Fly   434 FVVSFLFCFANHDVTFAIRTLLNK 457
            .:|:.:|||.|.:|...:|...|:
Mouse   377 LLVATIFCFFNGEVQAILRRNWNQ 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	31/66 (47%)
		7tm_4	216..436	CDD:304433	83/221 (38%)
Calcrl	NP_061252.2	HRM	61..128	CDD:397086	31/66 (47%)
		7tmB1_calcitonin_R	137..410	CDD:341343	101/269 (38%)
		TM helix 1	140..164	CDD:341343	10/23 (43%)
		TM helix 2	173..194	CDD:341343	7/20 (35%)
		TM helix 3	212..234	CDD:341343	9/21 (43%)
		TM helix 4	253..269	CDD:341343	4/15 (27%)
		TM helix 5	286..309	CDD:341343	8/22 (36%)
		TM helix 6	334..356	CDD:341343	13/21 (62%)
		TM helix 7	362..387	CDD:341343	8/24 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3536
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46801
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	1	1.000	-	-		mtm8762
orthoMCL	1	0.900	-	-		OOG6_105420
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780