DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and Gipr

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_006540205.1	Gene:	Gipr / 381853	MGIID:	1352753	Length:	502	Species:	Mus musculus

Alignment Length:	436	Identity:	108/436 - (24%)
Similarity:	182/436 - (41%)	Gaps:	99/436 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ELAEKEELMATVVSATMATNQKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNR--KFL 155
            ||.::.|.........:.|.:..:.|.|..:||.|.||..|.|.|.....||.::..|.:  ...
Mouse    30 ELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGF 94

  Fly   156 AHKTCLENGSWYRHPVSNQTWSNYTNCVD------YED----LEFRQFINELYVKGYALSLLALL 210
            ..:.|..:|.|       .:|.::|.|.:      ::|    ||..|.   :|..||:|||..||
Mouse    95 VFRQCGSDGQW-------GSWRDHTQCENPEKNGAFQDQTLILERLQI---MYTVGYSLSLTTLL 149

  Fly   211 ISIIIFLGFKSLRCTRIRIHVHLFASLACTCVAWILWYRLVVERSETI----------AENPLW- 264
            ::::|...|:.|.|||..||::||.|......|       ::.|.:.:          |..| |
Mouse   150 LALLILSLFRRLHCTRNYIHMNLFTSFMLRAAA-------ILTRDQLLPPLGPYTGDQAPTP-WN 206

  Fly   265 -----CIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPIPIAIVYG 324
                 |....::..|.:..||.|:..||::||.:||:|...:....|.::::.|.:|....|.:.
Mouse   207 QALAACRTAQIMTQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCYLLLGWGAPALFVIPWV 271

  Fly   325 LARHFSSPDNKHCWITDSL--YLWIFSVPITLSLLA----------------------------- 358
            :.|:..  :|..||..:.:  ..||...||.:::|.
Mouse   272 IVRYLR--ENTQCWERNEVKAIWWIIRTPILITILVGPVSPPPGCTQGFLILGKRSANPLSHPRN 334

  Fly   359 -------------SFIFLINVLRVIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYR 410
                         :|:..|.:|.::|.||..:..:.....:|.| |:|:.||||.|:...:  :.
Mouse   335 RMASGSVSLSSQINFLIFIRILGILVSKLRTRQMRCPDYRLRLA-RSTLTLVPLLGVHEVV--FA 396

  Fly   411 PDAGTQLD---HFYQM-LSVVLVSLQGFVVSFLFCFANHDVTFAIR 452
            |....|::   .|.:: ..:.|.|.|||:||.|:||.|.:|...||
Mouse   397 PVTEEQVEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIR 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	19/74 (26%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	63/283 (22%)
Gipr	XP_006540205.1	HRM	54..117	CDD:367186	19/69 (28%)
		7tmB1_GlucagonR-like	130..447	CDD:341353	84/329 (26%)
		TM helix 1	133..157	CDD:341353	10/26 (38%)
		TM helix 2	166..187	CDD:341353	6/27 (22%)
		TM helix 3	213..235	CDD:341353	5/21 (24%)
		TM helix 4	254..270	CDD:341353	3/15 (20%)
		TM helix 5	288..353	CDD:341353	6/64 (9%)
		TM helix 6	375..400	CDD:341353	10/27 (37%)
		TM helix 7	409..434	CDD:341353	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810