DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and Glp1r

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_036860.2	Gene:	Glp1r / 25051	RGDID:	2703	Length:	463	Species:	Rattus norvegicus

Alignment Length:	361	Identity:	96/361 - (26%)
Similarity:	170/361 - (47%)	Gaps:	32/361 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAH--KTCLENGSWYRHPVSNQTWSNYT 180
            |||...||.|.|||..|.|:.::..||.::...:.....|  :.|...|.|.....|:..|.:.:
  Rat    60 LFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLS 124

  Fly   181 NCVDYEDLEFRQFINE-------LYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLA 238
            .|.:.:..| |....|       :|..|||||..||:|:..|.:.|:.|.|||..||::||||..
  Rat   125 ECEESKQGE-RNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFI 188

  Fly   239 CTCVAWILWYRLVVERSETIAENPLW-----------CIGLHLVVHYFMLVNYFWMFCEGLHLHL 292
            ...::..:....:.....|.|:...|           |..:.|::.|.:..||:|:..||::|:.
  Rat   189 LRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYT 253

  Fly   293 VLVVVFVKDTIVMRWFIVISWFSPIPIAIVYGLARHFSSPDNKHCWITDS-LYLW-IFSVPITLS 355
            :|......:..:.:.::.|.|..|:...|.:|:.::..  :::.||..:| :..| |..:||..:
  Rat   254 LLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLY--EDEGCWTRNSNMNYWLIIRLPILFA 316

  Fly   356 LLASFIFLINVLRVIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPD---AGTQL 417
            :..:|:..|.|:.:::.||.........:..|.| ::|:.|:||.|....:..:..|   .||.
  Rat   317 IGVNFLIFIRVICIVIAKLKANLMCKTDIKCRLA-KSTLTLIPLLGTHEVIFAFVMDEHARGTL- 379

  Fly   418 DHFYQMLS-VVLVSLQGFVVSFLFCFANHDVTFAIR 452
             .|.::.: :...|.|||:|:.|:||.|::|....|
  Rat   380 -RFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	20/68 (29%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	56/236 (24%)
Glp1r	NP_036860.2	HRM	59..128	CDD:397086	20/67 (30%)
		7tmB1_GLP1R	141..419	CDD:341342	73/279 (26%)
		TM helix 1	144..168	CDD:341342	10/23 (43%)
		TM helix 2	177..198	CDD:341342	6/20 (30%)
		TM helix 3	227..249	CDD:341342	6/21 (29%)
		TM helix 4	268..284	CDD:341342	4/15 (27%)
		TM helix 5	302..325	CDD:341342	5/22 (23%)
		TM helix 6	350..372	CDD:341342	6/22 (27%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250\|UniProtKB:P43220	352..355		1/2 (50%)
		TM helix 7	381..406	CDD:341342	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810