DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and FBXO46

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001073938.1	Gene:	FBXO46 / 23403	HGNCID:	25069	Length:	603	Species:	Homo sapiens

Alignment Length:	215	Identity:	52/215 - (24%)
Similarity:	71/215 - (33%)	Gaps:	66/215 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DDPSFSLGPATDYDSDLPENFSPVPRYLENAA------MNEGVID---------MRNVDEELAEK 97
            |:.|....||.....|.|....|.|.....|:      :..||:|         .:||.||
Human   331 DEASEGDSPAPARPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDECIFFGKDGTKNVKEE---- 391

  Fly    98 EELMATVVSATMATNQ--KENRLFCPLNF--DGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAHK 158
                  .|..|::..:  ...:||...|.  ||....|  ||.:..:...||..||.....|..
Human   392 ------TVCLTVSPEEPPPPGQLFFLQNRGPDGPPEPP--PADSPATAPGPDDAEGTADTSLCR- 447

  Fly   159 TCLENGSWYRHPVSNQTWSNYTNCVDYEDLEFRQFINELYVKGYALSLLA--LLISIIIFLGFKS 221
                   .|||             |.::.||.|..|..|......:.||.  :|:.|..||..::
Human   448 -------LYRH-------------VSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRA 492

  Fly   222 LRCTRIRIHVHLFASLACTC 241
            |            |:|.|||
Human   493 L------------AALKCTC 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	17/68 (25%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	8/26 (31%)
FBXO46	NP_001073938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..360		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..440		12/45 (27%)
		F-box-like	473..>507	CDD:289689	12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900