DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hec and Pth2r

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_644676.1	Gene:	Pth2r / 213527	MGIID:	2180917	Length:	546	Species:	Mus musculus

Alignment Length:	429	Identity:	120/429 - (27%)
Similarity:	199/429 - (46%)	Gaps:	60/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 EELMATVVSATM------ATNQKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLA 156
            ||.:..|:.|.|      ....:|....|...:||.:||||...|.:.:..||.:|..||.|.:|
Mouse    35 EEQIVLVMKAKMQCELNITAQLQEGEGNCFPEWDGIICWPRGTVGKMSAVPCPPYVYDFNHKGVA 99

  Fly   157 HKTCLENGSWYRHPVSNQTWSNYTNCVDYEDL-----EFRQFINELYVKGYALSLLALLISIIIF 216
            .:.|..||:|.....||:||:||::|....|:     ||.:.:..||..||::|..:|.::|:|.
Mouse   100 FRHCTPNGTWDSIHGSNKTWANYSDCFLQPDINIGKQEFFESLYILYTVGYSISFGSLAVAILII 164

  Fly   217 LGFKSLRCTRIRIHVHLFASLACTCVAWILWYRLV--------------------------VERS 255
            ..|:.|.|||..||:|||.|.....::..:..|:.                          |::|
Mouse   165 GYFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKS 229

  Fly   256 ETIAENPLWCIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPIPIA 320
            :.:.     |....::..||:..||:|:..|||:||.::.|.|..||..:..||.|.|..|....
Mouse   230 QYVG-----CKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFISIGWGFPAVFV 289

  Fly   321 IVYGLARHFSSPDNKHCWITDSLYLWIFSVPITLSLLASFIFLINVLRVIVRKL-------HPQS 378
            :.:.:||  ::..:..||...:...||:..||..::..:||..:|.:||:..|:       |...
Mouse   290 VAWAVAR--ATLADTRCWELSAGDRWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMR 352

  Fly   379 AQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPDAGTQLDHFYQM-LSVVLVSLQGFVVSFLFCF 442
            .|     .||..::|::||.:||:.:.:...:|.:.:.|....:| ..:...|.|||.||.::|:
Mouse   353 KQ-----YRKLAKSTLVLVLVFGVHYIVFVCQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCY 412

  Fly   443 ANHDVTFAIR---TLLNKLLPSLVTPPPAGSNTGQMATT 478
            .|.:|...::   |..|..:.....||..|...|.:.||
Mouse   413 CNGEVQAEVKKMWTRWNLSIDWKRAPPCGGQRYGSVLTT 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	26/66 (39%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	64/253 (25%)
Pth2r	NP_644676.1	HRM	63..125	CDD:280888	25/61 (41%)
		7tm_2	139..406	CDD:278432	72/278 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..546
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810