DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and Pth1r

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_036010598.1	Gene:	Pth1r / 19228	MGIID:	97801	Length:	745	Species:	Mus musculus

Alignment Length:	471	Identity:	135/471 - (28%)
Similarity:	220/471 - (46%)	Gaps:	68/471 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RIFLKH-LYAECVFRYQNVTYDTDDP---SFSLGPATDYDSD---LPENFSPVPRYLENAAMNEG 83
            :|||.| ..|:|....:.|.:....|   :..:.||...:||   .|.:.|..||
Mouse   179 QIFLLHRAQAQCDKLLKEVLHTAAQPMARTTPISPANIMESDKGWTPASTSGKPR---------- 233

  Fly    84 VIDMRNVDEELAEKEELMATVVSATMATNQKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVE 148
                    :|.|..:....:..:..:.|..:.....|...:|..:|||....|.|::..|||::.
Mouse   234 --------KEKAPGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIY 290

  Fly   149 GFNRKFLAHKTCLENGSWYRHPVSNQTWSNYTNCVDYEDLEFRQ-----FINELYVKGYALSLLA 208
            .||.|..|::.|..||||...|..|:||:||:.|:.:...|.|:     .:..:|..||::||.:
Mouse   291 DFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLAS 355

  Fly   209 LLISIIIFLGFKSLRCTRIRIHVHLFASLACTCVA-----WILWYRLVVERSETIAENPLWCI-- 266
            |.::::|...|:.|.|||..||:|:|.|......:     .:|:....::.:|.:.|..|..|
Mouse   356 LTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQ 420

  Fly   267 -------------GLHLVVH---YFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFS 315
                         |..:.|.   ||:..||:|:..|||:||.::.:.|..:...:..|.:..|..
Mouse   421 VPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGL 485

  Fly   316 P-IPIAIVYGLARHFSSPDNKHCW-ITDSLYLWIFSVPITLSLLASFIFLINVLRVIVRKLHPQS 378
            | :.:|:..|:....:   |..|| ::.....||..|||..|::.:||..||::||:..||...:
Mouse   486 PAVFVAVWVGVRATLA---NTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETN 547

  Fly   379 AQPAPL--AIRKAVRATIILVPLFGLQH---FLLPYRPDAGT--QLDHFYQMLSVVLVSLQGFVV 436
            |.....  ..||.:|:|::||||||:.:   ..|||...:||  |:...|:||   ..|.|||.|
Mouse   548 AGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEML---FNSFQGFFV 609

  Fly   437 SFLFCFANHDVTFAIR 452
            :.::||.|.:|...||
Mouse   610 AIIYCFCNGEVQAEIR 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	26/66 (39%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	74/251 (29%)
Pth1r	XP_036010598.1	PHA03247	<6..113	CDD:223021
		HRM	259..324	CDD:397086	25/64 (39%)
		7tm_GPCRs	338..630	CDD:421689	88/294 (30%)
		TM helix 1	340..365	CDD:410628	7/24 (29%)
		TM helix 2	374..396	CDD:410628	5/21 (24%)
		TM helix 3	436..463	CDD:410628	11/26 (42%)
		TM helix 4	475..495	CDD:410628	4/19 (21%)
		TM helix 5	510..539	CDD:410628	11/28 (39%)
		TM helix 6	556..583	CDD:410628	11/26 (42%)
		TM helix 7	592..617	CDD:410628	11/27 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810