Protein Alignment hec and Glp1r

DIOPT Version :9

• Sequence 1: NP_001285174.1
• Gene: hec / 32246
• FlyBaseID: FBgn0030437
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_067307.2
• Gene: Glp1r / 14652
• MGIID: 99571
• Length: 463
• Species: Mus musculus
• Alignment Length: 361
• Identity: 98/361 - (27%)
• Similarity: 171/361 - (47%)
• Gaps: 32/361 - (8%)

  Fly   118 LFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAH--KTCLENGSWYRHPVSNQTWSNYT 180
            |||...||.|.|||..|.|:.::..||.::...:.....|  :.|...|.|.....|:..|.:.:
Mouse    60 LFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLS 124

  Fly   181 NCVDYEDLEFRQFINE-------LYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLA 238
            .|.:.:..| |.|..|       :|..|||||..||:|:..|.:||:.|.|||..||::||||..
Mouse   125 ECEESKRGE-RNFPEEQLLSLYIIYTVGYALSFSALVIASAILVGFRHLHCTRNYIHLNLFASFI 188

  Fly   239 CTCVAWILWYRLVVERSETIAENPLW-----------CIGLHLVVHYFMLVNYFWMFCEGLHLHL 292
            ...::..:....:.....|.|:...|           |..:.|::.|.:..||:|:..||::|:.
Mouse   189 LRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYT 253

  Fly   293 VLVVVFVKDTIVMRWFIVISWFSPIPIAIVYGLARHFSSPDNKHCWITDS-LYLW-IFSVPITLS 355
            :|......:..:.:.::.|.|..|:...|.:|:.::..  :::.||..:| :..| |..:||..:
Mouse   254 LLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLY--EDEGCWTRNSNMNYWLIIRLPILFA 316

  Fly   356 LLASFIFLINVLRVIVRKLHPQSAQPAPLAIRKAVRATIILVPLFGLQHFLLPYRPD---AGTQL 417
            :..:|:..|.|:.::|.||.........:..|.| ::|:.|:||.|....:..:..|   .||.
Mouse   317 IGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLA-KSTLTLIPLLGTHEVIFAFVMDEHARGTL- 379

  Fly   418 DHFYQMLS-VVLVSLQGFVVSFLFCFANHDVTFAIR 452
             .|.::.: :...|.||.:|:.|:||.|::|....|
Mouse   380 -RFIKLFTELSFTSFQGLMVAILYCFVNNEVQMEFR 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	20/68 (29%)
		7tm_4	216..436	CDD:304433	57/236 (24%)
Glp1r	NP_067307.2	HRM	59..128	CDD:280888	20/67 (30%)
		7tm_2	141..398	CDD:278432	67/261 (26%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220	352..355		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810