DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hec and Ghrhr

DIOPT Version :9

Sequence 1:	NP_001285174.1	Gene:	hec / 32246	FlyBaseID:	FBgn0030437	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_036021736.1	Gene:	Ghrhr / 14602	MGIID:	95710	Length:	444	Species:	Mus musculus

Alignment Length:	302	Identity:	78/302 - (25%)
Similarity:	126/302 - (41%)	Gaps:	40/302 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DEELAEKEELMATVVSATMATNQKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKF- 154
            |:|||        .:.|...||  ...|.||..:||.||||.|.:|..:|..||:|...|....
Mouse    36 DDELA--------CLQAAEGTN--NTSLGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDTG 90

  Fly   155 LAHKTCLENGSWYRHPVSNQTWSN----Y-TNC-VDYE----DLEFRQFINELYVKGYALSLLAL 209
            ...:.|...|           |||    | ..| |..|    :..:...:..:|..|:::|::||
Mouse    91 FVKRDCTITG-----------WSNPFPPYPVACPVPLELLTKEKSYFSTVKIIYTTGHSISIVAL 144

  Fly   210 LISIIIFLGFKSLRCTRIRIHVHLFASLACTCVAWILWYRLVVERSET--IAENPLWCIGLHLVV 272
            .::|.|.:..:.|.|.|..||..|||:......|..|....:.:...|  .:.:.:.|.....:.
Mouse   145 CVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAIFQGDSTDHCSMSTVLCKVSVAIS 209

  Fly   273 HYFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPIPIAIVY-GLARHFSSPDNKH 336
            |...:.|:.|:..|.::|..:|.....:......|.::..|..|:.....: |....|   ::..
Mouse   210 HLATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAF---EDTE 271

  Fly   337 CWITD--SLYLWIFSVPITLSLLASFIFLINVLRVIVRKLHP 376
            ||..|  |...||...||.||:..:|...:|::.:::|||.|
Mouse   272 CWDLDNSSPCWWIIKGPIVLSVGVNFGLFLNIICILLRKLEP 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hec	NP_001285174.1	HRM	118..185	CDD:280888	24/73 (33%)
hec	NP_001285174.1	7tm_4	216..436	CDD:304433	39/166 (23%)
Ghrhr	XP_036021736.1	HRM	53..112	CDD:397086	22/69 (32%)
		7tm_GPCRs	126..>325	CDD:421689	46/191 (24%)
		TM helix 1	128..153	CDD:410628	7/24 (29%)
		TM helix 2	162..184	CDD:410628	7/21 (33%)
		TM helix 3	203..230	CDD:410628	5/26 (19%)
		TM helix 4	242..262	CDD:410628	3/19 (16%)
		TM helix 5	278..307	CDD:410628	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810